[ Back to EurekAlert! ] Public release date: 2-Dec-2009
[ | E-mail Share Share ]

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-319-22165
BioMed Central

Hope for men with nonobstructive infertility

It has been thought that men with non-obstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for IVF. Now, researchers writing in the open access journal Reproductive Biology and Endocrinology have shown that sperm from men with NOA and obstructive azoospermia (OA) are equally capable of producing embryos.

Nina Desai led a team of researchers from the Cleveland Clinic Foundation who carried out an in-depth analysis of intracytoplasmic sperm injection (ICSI) using frozen sperm taken from the testes of 44 men with OA and 17 men with NOA. They found that, although fertilization rates were slightly improved in the OA group, there were no significant differences in implantation rates or clinical pregnancy rates. According to Desai, "The high implantation rate per embryo transferred and the resultant live births attest to the quality of embryos being produced with both types of surgically retrieved sperm".

In addition to evaluating the feasibility of NOA sperm, the researchers were also able to study paternal effect on genomic activation. One of the earliest morphologic indicators of embryonic genome activation is increased cell-to-cell adherence at the 8-cell stage, leading to compaction. Desai said, "Interestingly, we found that embryonic compaction was similar in all three groups. These results suggest that zygotic activation is independent of sperm origin and type of azoospermia".

###

Notes to Editors:

1. Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa
Nina Desai, Faten AbdelHafez, Edmund Sabanegh and James Goldfarb
Reproductive Biology and Endocrinology (in press)

During embargo, article available here: http://www.rbej.com/imedia/1994596466296468_article.pdf?random=950443

After the embargo, article available at journal website: http://www.rbej.com/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication

2. Reproductive Biology and Endocrinology (RB&E) is an Open Access, peer-reviewed, online journal aiming for the wide distribution of results from excellent research in the reproductive sciences.

RB&E represents a global platform for reproductive and developmental biologists, reproductive endocrinologists, immunologists, theriogenologists, infertility specialists, obstetricians, gynecologists, andrologists, urogynecologists, specialists in menopause, reproductive tract oncologists, and reproductive epidemiologists.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.