News Release

European Research Council grant for neuroscience research

Scientist of the Champalimaud Neuroscience Programme at the Instituto Gulbenkian de Ciencia amongst winners of largest European research grant

Grant and Award Announcement

Instituto Gulbenkian de Ciencia

Zachary Mainen, Instituto Gulbenkian de Ciencia

image: Zachary Mainen, coordinator of the Champalimaud Foundation Neuroscience Programme at the Instituto Gulbenkian de Ciencia, in Portugal, was awarded one of the Advanced Investigator Grants of the European Research Council, for research into the biological role of serotonin in the nervous system. view more 

Credit: Fundação Champalimaud

Zachary Mainen, coordinator of the Champalimaud Foundation Neuroscience Programme at the IGC, has become one of the most recent winners of the prestigious and highly competitive European Research Council grants, to the value of 2.3 million euro, for a period of five years. This grant, which recognises Mainen's contribution to the Neuroscience field, will be used to elucidate the biological role of the neurotransmitter serotonin. The ERC is the most prominent European organism supporting scientific research. Zachary Mainen, north-american, has published over 30 studies in leading scientific journals. In 2007 he left the Cold Spring Harbour Laboratory for the Neuroscience Programme and is now living in Portugal.

Zachary Mainen and his group propose to shed light on one of the most enigmatic topics in Neuroscience - the exact role of serotonin in controlling vital behaviours such as eating, sleeping or breathing, and associated psychiatric disorders, such as anxiety, depression, migraine or eating disorders.

According to Mainen, "Anti-depressant drugs such as Prozac increase levels of serotonin in the brain, but little is known about what causes the brain to release its own serotonin or exactly how it affects the functioning of the nervous system. We are developing novel tools that will allow us to make definitive tests of serotonin function and gain insight into how this very important neurotransmitter actually functions in the brain. Ultimately, our studies may have clinical applications, as they may contribute to more effective drugs for behavioural disorders or ultimately to more advanced genetic therapies."

The tools the team of scientists is developing, based on genetics, optical imaging and electrophysiology (recording the electrical activity of nerve cells), are a valuable resource for the entire scientific community, across the world.

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The Advanced Investigator Grant which Zachary Mainen has just received is awarded to senior researchers, and is aimed at encouraging and supporting innovative and ground-breaking projects, on the basis of scientific excellence alone, in any field of research. In this second edition of these grants, a total of 512 applications were received, from across Europe. This grant is the first awarded to a senior life scientist working in Portugal.

Zachary Mainen - Born in Rockville, USA, Zachary Mainen was educated at Yale University before receiving his Ph.D. in Neurosciences from the University of California in 1995. Following his Ph.D. Dr Mainen worked as a Postdoctoral Fellow in the Laboratory of Roberto Malinow at Cold Spring Harbor Laboratory, USA, until 1997 and then moved to the laboratory of Karel Svoboda in the same institution where he stayed until 1999. He was appointed Assistant Professor at Cold Spring Harbor Laboratory in 1999 and then went on to attain the position of Associate Professor, which he occupied from 2004 to 2007. He is a visiting investigator at Howard Hughes Medical Institute (HHMI) Janelia Farm. He joined the Champalimaud Neuroscience Programme in 2007, as Senior Investigator and Coordinator.


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