[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:
22-Mar-2010

[ | E-mail ] Share Share

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press

Bloom's syndrome protein is critical for meiotic recombination

Researchers from Cornell University (NY) provide the first analysis of the function of Bloom's syndrome protein (BLM) in mammalian meiosis. Bloom's syndrome (BS) is a rare genetic disorder characterized by stunted growth, cancer predisposition, and sterility that is caused by a mutation in the Blm gene and a deficiency of BLM. The study appears in the March 22 issue of the Journal of Cell Biology (www.jcb.org).

Although BLM has been shown to play an important role in DNA recombination in somatic cells, there has been no information on the impact of BLM in mammalian meiosis. Now, a team led by Paula Cohen provides new data that indicate mouse BLM is involved in the proper pairing, synapsis, and segregation of homologous chromosomes during meiosis, but does not affect entry into the prophase I stage.

###

About the Journal of Cell Biology

Founded in 1955, the Journal of Cell Biology (JCB) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit www.jcb.org.

Holloway, J.K., et al. 2010. J. Cell Biol. doi:10.1083/jcb.200909048.



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.