ANN ARBOR, Mich. – A University of Michigan study recently published in Academic Emergency Medicine says that it is common for patients 65 and older to receive potentially inappropriate medications when treated in an emergency room.
Nearly 19.5 million older patients, or 16.8 percent of eligible emergency visits from 2000-2006, received one or more potentially inappropriate medications – or PIMs. The large sample of approximately 470,000 ED and outpatient clinic visits, corresponding to a national estimate of about 1.5 billion total visits, allowed the researchers to determine the extent of the problem nationwide.
"There are certain medications that probably are not good to give to older adults because the potential benefits are outweighed by potential problems," says lead author, William J. Meurer, M.D., M.S., assistant professor, U-M Departments of Emergency Medicine and Neurology.
Researchers looked at a nationwide sample of emergency visits using data from the National Hospital Ambulatory Medical Care Survey, to see how many patients aged 65 and older sent home from the ED were prescribed potentially inappropriate medications.
Ten medications accounted for 86.5 percent of PIMs used in the ED. The five most common ones were promethazine, ketorolac, propoxyphene, meperidine, and diphenhydramine; and two of these – promethazine and ketorolac – accounted for nearly 40%.
Meurer suggested that further efforts are needed to educate doctors about the suitability of certain medications for older adults.
He also says the study showed that prescribing inappropriate medications was less likely to occur if a resident or intern was involved in the treatment, probably due to the fact that younger doctors have had recent training about medications.
There was substantial regional and hospital type (teaching vs. non-teaching) variability. PIMs were less likely to occur in visits to hospitals in the Northeast and twice as likely in other parts of the country. And receiving a potentially inappropriate medication was more likely to occur at for-profit hospitals.
The study did not explore the possibility of medication interactions, so it is possible that the potential harm by medications is underestimated.
Meurer offers the following advice to patients:
Additional authors: Tommy A. Potti; Kevin A. Kerber, M.D., M.S.; Comilla Sasson, M.D., M.S.; Michelle L. Macy, M.D., Brady T. West, M.S.; and Eve D. Losman, M.D. All are part of the University of Michigan Health System.
Funding: The authors have no conflicts of interest to report. Meurer and Potti received support from the Summer Research Training in Aging for Medical Students program from the Natioanl Institutes of Health, National Institutes of Aging.
Reference: Academic Emergency Medicine 2010; 17: 231-237
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