Esophagectomy is a standard treatment for resectable esophageal carcinoma but relatively few patients are cured. Combined neoadjuvant chemoradiotherapy (CRT) or adjuvant CRT with surgery may improve survival but there is concern about treatment morbidity and the best sequencing of CRT and surgery.
A research team from China used a prospective study, based on randomized controlled trial design, to compare preoperative and postoperative CRT to surgery alone in patients with resectable esophageal squamous cell carcinoma (ESCC). Their study will be published on April 7, 2010 in the World Journal of Gastroenterology.
With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year overall survival (OS) and progression-free survival (PFS) were detected among the the preoperative CRT, postoperative CRT and surgery groups, respectively. There were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm. For the patients who had radical resection, significant differences in median PFS and median OS were detected among the 3 arms, but there were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm. The local recurrence rates in the preoperative CRT, postoperative CRT group and S group were 11.3%, 14.1% and 35%, respectively. No significant differences were detected among the 3 groups when comparing complications but tended to be in favor of the postoperative CRT and S groups. Toxicities of CRT in the preoperative or postoperative CRT arms were mostly moderate, and could be quickly alleviated by adequate therapy.
Their results illustrated that long-term survival is maximized by the use of CRT followed by surgery for locally advanced esophageal cancer. However, patients are more likely to develop toxicity. As therapies improve, it is likely that the toxicity may be reduced and neoadjuvant CRT may provide a more marked benefit in esophageal cancer. Meanwhile, postoperative CRT can also be safely administered and considered as the multimodal treatment of choice for locally advanced ESCC.
Reference: Lv J, Cao XF, Zhu B, Ji L, Tao L, Wang DD. Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma. World J Gastroenterol 2010; 16(13): 1649-1654 http://www.
Correspondence to: Xiu-Feng Cao, Professor, Department of Surgery, Oncology Center, Affiliated Nanjing First Hospital of Nanjing Medical University and Oncology Center of Nanjing Medical University, 68 Changle Road, Nanjing 210006, Jiangsu Province, China. email@example.com Telephone: +86-25-52887061 Fax: +86-25-52269924
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.