Which treatment is effective in maintaining remission in ulcerative colitis: Probiotic or placebo?

Inflammatory bowel disease is a chronic recurrent disease, which mainly consists of ulcerative colitis and Crohn's disease, and whose causes are as yet unclear. Many clinical and research studies have indicated that intestinal flora dysbacteriosis contributes to the pathogenesis of ulcerative colitis. Probiotics are non-pathogenic beneficial flora, which have important effects on maintaining the balance of intestinal flora. Many studies have discussed the positive effects of probiotics for treating stomach and intestine diseases, including ulcerative colitis. However, the sample size has been relatively small, such that there is no definitive evidence as to whether probiotics are helpful.

A research team from China systematically evaluated probiotics' curative effects for treating ulcerative colitis based on existing random control trials. Their study will be published on April 21, 2010 in the World Journal of Gastroenterology.

Through meta-analysis, they concluded that probiotics should be considered as an auxiliary medicine in the remission induction stage and maintenance stage of ulcerative colitis.

Reference: Sang LX, Chang B, Zhang WL, Wu XM, Li XH, Jiang M. Remission induction and maintenance effect of probiotics on ulcerative colitis: A meta-analysis. World J Gastroenterol 2010;16(15): 1908-1915

http://www.wjgnet.com/1007-9327/full/v16/i15/1908.htm

Correspondence to: Min Jiang, Professor, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China. sanglixuan2008@sohu.com

Telephone: +86-24-83282209 Fax: +86-24-83282208

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H. pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.