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PUBLIC RELEASE DATE:
18-May-2010

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Contact: Timo Ahopelto
timo.ahopelto@oncos.com
358-400-569-628
University of Helsinki
@helsinkiuni

Oncolytic viruses mediating anti-tumor immunity in human cancer patients

The researchers of the University of Helsinki, and Oncos Therapeutics, the biotech company developing new cancer therapeutics based on the next generation oncolytic viruses, published initial results from their Advanced Therapy Access Program in Cancer Research. The therapy program is based on scientific research at the University of Helsinki and serves as the foundation for ongoing clinical development.

The results demonstrate an anti-tumor immunity of oncolytic viruses - published for the first time in humans - and indicate the strong efficacy of the next generation viruses against solid tumor cancers. As of today, 200 patients have been treated with oncolytic virus therapy in the company's Advanced Therapy Access Program.

"This is the first time it has been shown in humans that oncolytic viruses can be used for the induction of anti-tumor immunity. The GMCSF -armed oncolytic adenovirus can mediate anti-tumor immunologic responses by recruiting natural killer cells and by the induction of tumor-specific cytotoxic T-cells", explains research professor Akseli Hemminki, the CSO and co-founder of Oncos.

"Anti-tumor immunity plays a major role in the strong efficacy results. We are starting clinical trials with CGTG-102, which is further improved compared of the virus described in this publication", comments Pekka Simula, the CEO and co-founder of Oncos.

The Cancer Research article reports strong safety and efficacy results in patients with advanced cancer progressing after available chemotherapy options. Out of the 15 radiologically evaluable patients 2 had complete responses (13%), 5 patients had stable disease (33 %) and 1 had a partial response (6 %). Therefore, the clinical benefit rate was 47% according to the RECIST criteria. Responses were frequently seen in both injected and non-injected tumors. The safety profile was favorable with no grade 4-5 side effects realized.

"It has been impressive to see how powerful and consistent the oncolytic adenovirus platform is for directing the body's own immune system against tumor cells" says Dr. Vincenzo Cerullo, the scientist who led the project at the University of Helsinki Cancer Gene Therapy Group (CGTG).

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About University of Helsinki and Cancer Gene Therapy Group (CGTG)

Founded in 2002, CGTG is the largest research group in Europe focusing on oncolytic virus therapies for the treatment of cancer. CGTG operates in the Biomedicum research and teaching institute at the University of Helsinki and consist of 27 researchers from 6 European countries. For more information about CGTG visit: http://www.hi.helsinki.fi/cgtg

About Oncos Therapeutics

Oncos Therapeutics develops new cancer therapies based on its next generation oncolytic viruses. The company's unique Advanced Therapy Access Program was started in 2007 for cancer patients in whom standard-of-care therapies have failed. Today, 200 patients have undergone individually tailored oncolytic virus therapy suggesting strong safety and efficacy. The program is based on scientific research at the University of Helsinki and serves as the foundation for ongoing clinical development. Oncos Therapeutics publishes an oncolytic virus blog: www.oncolyticvirus.wordpress.com. For more information about Oncos visit: www.oncos.com.

About oncolytic adenovirus CGTG-102

The oncolytic virus CGTG-102 is the lead candidate of Oncos Therapeutics. This modified oncolytic adenovirus combines the established safety of adenovirus therapies with GM-CSF arming and improved tumor cell transduction via capsid modification. The unique design enables high tumor selectivity, sustained anti-tumor immune response, body-wide efficacy, and a very acceptable side effect profile. So far, 18 solid tumor cancers and 200 patients have been treated with CGTG-102, with the data suggesting broad applicability across cancer types.



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