Public Release:  Targeted radioisotope generator could be used for molecular imaging

Development of a new generator could diversify the number of agents currently available for use with positron emission tomography

Society of Nuclear Medicine

SALT LAKE CITY--According to a study presented at SNM's 57th Annual Meeting, a new radioisotope generator could enhance images produced by a molecular imaging technique known as positron emission tomography (PET). The generator, in combination with instant synthesis kits that introduce target constituents like peptides to the mix, could be used to produce molecular imaging agents that enhance the range of targeting capabilities in diagnostic scans, providing physicians with a much broader portrait of how biological processes are working and why.

"This generator is one more advanced technology that can improve the treatment of cancer, cardiovascular conditions and other common conditions," said Jeffrey Lacy, Ph.D., president of Houston-based Proportional Technologies, Inc. "For example, this technology has been shown to be especially effective for measuring myocardial blood flow and renal function.

Physicians could use this technology to more precisely evaluate blood flow through blood vessels and vital tissues, as well as more accurately target treatment for a broad range of cancers."

Using this generator, physicians would be able to inject peptide-labeled agents containing extremely small levels of the targeting peptide, which homes in on biological processes in the body. Only a small number of PET imaging agents are currently available due to their short half-lives, which require daily production and synthesis at more than 100 radiopharmacies across the country. The new generator would depend on a longer-lived parent isotope (9.3 hr Zn-62) that is relatively easily distributed and obtained, and physicians synthesize and inject the subsequent Cu-62, a copper-based agent, in a matter of minutes prior to scanning.

In this study, investigators miniaturized and redesigned components of a larger-scale generator approved for human investigational studies and tested the system for peptide specific activity using a peptide that targets a melanoma receptor called melanoma-1. Melanoma-bearing mice were injected with the peptide-labeled imaging agent and underwent PET imaging. Tumors showed rapid receptor-specific uptake of the agent with specific activity as high as 200 Ci/umol (a measurement of radioactivity in microcuries per micromolar concentration). Results showed that the generator and kit system was able to instantly label the radioactive copper isotope without further purification. The agent produced by this system has been shown to be favorable to human studies, and may improve upon the image quality of similar copper-based agents.

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Scientific Paper 254: Z.D. Yue, B. Lu, G.J. Vazquez-Flores, J. Yuen, J.L. Lacy, Proportional Technologies, Inc., Houston, Texas; X. Zhang, T.P. Quinn, University of Missouri, Columbia, Mo; "A new Cu-62 generator for high specific activity peptide PET imaging," SNM's 57th Annual Meeting, June 5𔃇, 2010, Salt Lake City, Utah.

About SNM--Advancing Molecular Imaging and Therapy

SNM is an international scientific and medical organization dedicated to raising public awareness about what molecular imaging is and how it can help provide patients with the best health care possible. SNM members specialize in molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated.

SNM's more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.snm.org.

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