[ Back to EurekAlert! ] Public release date: 20-Sep-2010
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Contact: Anna Borthwick
anna.borthwick@ed.ac.uk
44-131-651-4400
University of Edinburgh

Study gets measure of how best to prevent blood clots

Treating hospital patients with thigh-length surgical stockings, rather than knee-high socks, can reduce life threatening blood clots, a new study suggests.

Researchers found that knee-high stockings, which are similar to flight socks, do little in stroke patients to prevent deep vein thrombosis (DVT), a life threatening form of blood clot that can travel up into the heart and lungs, .

The CLOTS (Clots in Legs Or sTockings after Stroke) study from the University of Edinburgh highlights that the clot rate in stroke patients was higher among those fitted with the shorter stockings than for those with longer stockings.

Another study, published last year by the same researchers, showed that thigh-length stockings did not usefully cut the risk of DVT in stroke patients.

This new study shows that short stockings are even less likely to help patients. The National Institute for Clinical Excellence have changed their guidelines based on these findings and no longer recommends that stockings are used for stroke patients.

However, stockings are also very widely used to prevent blood clots in patients who undergo surgery. Clinicians mostly use short stockings, which are cheaper and easier to fit than thigh-length stockings. In Scotland, for example, about three-quarters of stockings used by the NHS are short.

This study questions whether the widespread use of short stockings is appropriate given the greater risk of clots associated with their use. Use of short stockings may result in many more patients suffering potentially life-threatening clots.

The CLOTS trial included more than 3,000 stroke patients from 112 hospitals in nine countries. It is by far the biggest study to test stockings.

Stroke patients fitted with below-the-knee, stockings were 30 per cent more likely to develop deep vein thrombosis than patients fitted with thigh-length stockings. This could be because the most serious type of blood clots tend to be in the thigh, researchers suggest,

Martin Dennis, Professor of Stroke Medicine at the University of Edinburgh, said: "Although we have shown in previous work that thigh-length stockings are not very effective in reducing the risk of DVT after a stroke, we believe that the results of this trial may have important implications for the millions of patients undergoing surgery each year."

"Millions of patients worldwide are fitted with stockings each year. Unless reliable evidence emerges that short stockings do actually reduce the risk of DVT, long stockings should always be used in preference."

Although trials have shown that stockings reduce the risk of DVT in patients undergoing surgery, these have only tested long stockings. The researchers have not identified any studies which show that below-knee stockings work.

David Clark, Chief Executive of Chest Heart & Stroke Scotland, said, "More than 150,000 people a year have a stroke in the UK and it is vital they receive the best possible treatment. This important research, which was seed funded by Chest Heart & Stroke Scotland , shows conclusively that short compression stockings do not benefit stroke patients. We can now focus our efforts and research funding on finding a treatment which will reduce the risk of clots. "

The team from Edinburgh are now testing another type of device which actively massages the legs to keep the blood moving which they hope will prevent CLOTS in stroke patients. The results from that trial are expected in about three years.

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The CLOTS Clots in Legs or sTockings after Stroke trial was funded by the Medical Research Council (UK), the Chest Heart & Stroke Scotland charity and the Scottish Government Chief Scientist Office. The research was published in the journal The Annals of Internal Medicine.



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