Patients returning to dialysis after kidney transplant failure present unique challenges compared with other dialysis patients: they have been exposed to very powerful immunosuppressive medications and have been on dialysis for a longer period of time than other dialysis patients. This puts them at particularly high risk for various complications and death. According to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN), despite complications, these patients can choose to undergo dialysis in the comfort of their own homes.
Patients who have had a kidney transplant are used to managing their own therapy, enjoying the ability to travel, and living a relatively flexible lifestyle and may therefore be well-suited to peritoneal dialysis (home-based) rather than hemodialysis (clinic-based), when they return to dialysis after transplant failure. Despite the many potential benefits of peritoneal dialysis over hemodialysis—including ease of performing the therapy at home, avoidance of hospital visits several times a week, and more flexibility to travel—only a very small proportion of patients returning to dialysis after transplant failure end up choosing to undergo peritoneal dialysis in both Canada and the United States.
Jeffrey Perl, MD (St. Michael's Hospital, University of Toronto, Canada) and his colleagues evaluated the impact that dialysis type (peritoneal vs. hemodialysis) has on the survival of patients returning to dialysis after transplant failure. The investigators studied 2,110 adult Canadian patients who initiated dialysis after their kidney transplant failed between January 1991 and December 2005. The researchers evaluated the impact of initial dialysis type on early (2-year), late (after 2 years), and overall deaths.
Hemodialysis and peritoneal dialysis patients died at similar rates in all analyses (early, late, and overall). "It is important to empower patients who have kidney transplant failure to realize that despite the severe disappointment of returning to dialysis, they still have many options for dialysis therapy, which include opportunities for home-based therapies," said Dr. Perl. "I hope this research helps guide patients and the health care professionals treating them to make informed decisions regarding dialysis modality decisions, namely that peritoneal dialysis is as effective a therapy as hemodialysis in patients returning to dialysis after kidney transplant failure."
Study co-authors include Omar Hasan, MBBS (Brigham and Women's Hospital); Joanne Bargman, MD, S. Vanita Jassal, MD (University of Toronto, Canada); Depeng Jiang, PhD (Li Ka Shing Knowledge Institute and St. Michael's Hospital, University of Toronto, Canada); Yingbo Na (Canadian Institute of Health Information and Canadian Organ Replacement Register, in Toronto, Canada); and John Gill, MD (St. Paul's Hospital, University of British Columbia, in Vancouver, Canada).
Disclosures: Jeffrey Perl received funding from a Kidney Foundation of Canada Biomedical Fellowship. The other authors reported no financial disclosures.
The article, entitled "Impact of Dialysis Modality on Survival after Kidney Transplant Failure," will appear online at http://cjasn.asnjournals.org/ on January 13, 2011, doi 10.2215/CJN.06640810.
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