Exposure to worm infections in the womb may protect a newborn infant from developing eczema, a study funded by the Wellcome Trust suggests. A large trial in Uganda showed that treating a pregnant woman for worm infections increased her child's chances of developing the allergic skin disease.
Published this week in the journal Pediatric Allergy and Immunology, the research supports the so-called 'hygiene hypothesis', which proposes that exposure to infections in early childhood can modify the immune system and protect the child from allergies later in life.
The World Health Organisation estimates that one in five of the world's population suffers from allergic diseases such as asthma and eczema, but this epidemic is no longer restricted to developed countries: more than four out of five deaths due to asthma occur in low and lower-middle income countries. The declining incidence and prevalence of infectious diseases – including chronic infection by worms known as helminths – is widely considered to be an important contributor contributing to this increase.
Helminth infection can cause symptoms ranging from mild anaemia through to stomach pain and vomiting, depending on how intense the infection is, but very often people have no symptoms at all. The parasitic worms tend to enter the body through contaminated food or water, mosquito bites or through walking in bare feet on contaminated soil.
A preliminary study carried out at the MRC/UVRI Uganda Research Unit on AIDS in Entebbe, Uganda in 2005 showed a reduced risk of eczema among infants whose mothers had worms and suggested an increased incidence among infants of mothers who received albendazole – a commonly used drug to treat worm infection – during pregnancy compared to infants whose mothers received a placebo.
In a follow-up study, researchers carried out a randomised, double-blind trial on 2,507 pregnant women in Uganda, comparing those treated with either albendazole or a second drug, praziquantel, against those administered a placebo, and looking at how this affected their offspring's risk of developing eczema.
Harriet Mpairwe, first author of the new study, says: "Worm infections can adversely affect a person's health, but the evidence also suggests that exposure to infection early in a child's life can have a beneficial effect in terms of modifying its immune system and protecting against allergies. We wanted to examine in a large cohort what effect de-worming women during pregnancy has on their offspring."
The researchers showed for the first time that treatment of pregnant women with albendazole appeared to almost double the risk of eczema in their offspring (an increase by a factor of 1.8) and that treatment with praziquantel more than doubled (an increase by a factor of 2.6) the risk of eczema among infants of mothers infected by the Schistosoma mansoni worm (a parasite which causes the disease schistosomiasis).
The findings support the hypothesis that maternal worms during pregnancy, neonatal life and early breastfeeding, may protect against allergy in infancy and that treatment of these worms during pregnancy increases the risk of allergy.
Professor Alison Elliott from the London School of Hygiene and Tropical Medicine, senior author of the study, says: "Our study suggests that routine de-worming during pregnancy, in settings where most worm infections are mild, may not be beneficial for the children and may actually cause problems with allergy. However, before we recommend changes to treatment policy, we need to do more work to confirm these findings and better understand what is happening.
"The findings certainly support the so-called 'hygiene hypothesis'. What will be important for the eczema story will be to see whether there are long term effects on allergy, especially asthma, at school age. Our next step is to investigate this further."
The research comes as Wellcome Collection prepares to open a major exhibition Dirt: The Filthy Reality of Everyday Life, exploring our relationship to dirt and hygiene across the centuries. The exhibition opens on 24 March 2011. See www.wellcomecollection.org/dirt for further details.
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