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15-Feb-2011

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Contact: Katie Hickling
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PLOS

Ion-exchange water softeners do not improve eczema in children

Water softeners provide no additional clinical benefit to usual care in children with eczema, so the use of ion-exchange water softeners for the treatment of moderate to severe eczema in children should not be recommended. However, it is up to each family to decide whether or not the wider benefits of installing a water softener in their home are sufficient to consider buying one. These are the findings of a study by Kim Thomas from the University of Nottingham, Nottingham, UK, and colleagues and published in this week's PLoS Medicine.

The authors conducted their randomised controlled trial among 336 children--who all lived in hard water areas in England--aged 6 months to 16 years with a diagnosis of eczema; they were randomised to receive either installation of an ion-exchange water softener plus usual eczema care, or usual eczema care alone for 12 weeks. Research nurses measured each child's eczema severity score at baseline and at 6, 12, and 16 weeks to record changes in eczema severity. The authors also analysed any changes in eczema symptoms over the study period such as sleep loss, itchiness, and the amount of topical treatments used.

Although both treatment groups improved in disease severity during the course of the trial, there were no clinically important differences between the groups in any of the outcomes that were measured objectively (without knowledge of the treatment that the child received). However, parents in the trial did report small health benefits in some of the more subjective outcomes, such as sleep loss and itchiness, and just over 50% chose to buy the water softener at the end of the trial because of perceived improvements in the eczema and the wider benefits of water softeners.

The authors say: "The results of this study are clear, and as a result we cannot recommend the use of ion-exchange water softeners for the treatment of moderate to severe eczema in children."

They add, "Whether or not the wider benefits of installing a water softener in the home are sufficient to justify the purchase of a softener is something for individual householders to consider on a case by-case basis."

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Funding: This trial was funded by the National Institute for Health Research, Health Technology Assessment (NIHR HTA) Programme, project number HTA 05/16/01. The views and opinions expressed in this article are those of the authors and do not necessarily reflect those of the NIHR HTA Programme. A consortium of water industry representatives helped with this study: Aqua Belgica, Culligan International (UK) Ltd, Ecowater Systems Ltd, Harvey Softeners Ltd, Kennet Water Components Ltd, Kinetico UK Ltd, Monarch Water, Salt Manufacturers Association, and the Water Quality Association (USA). They provided technical advice, generic water softeners, fittings, salt, and analytical testing of the weekly water samples. This assistance was coordinated through the UK Water Treatment Association, which is an independent trade association for the industry. Funding for pilot work for this trial was provided by Kinetico UK Ltd. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: AF is Technical Director of the UK Water Treatment Association, which represents the interests of manufacturers of water treatment equipment used in private and public water supplies. The range of equipment covered includes water softeners. He is a consultant to the European Water Treatment Association with similar interests, and is International Director (unpaid) for the USA Water Quality Association.

Citation: Thomas KS, Dean T, O'Leary C, Sach TH, Koller K, et al. (2011) A Randomised Controlled Trial of Ion-Exchange Water Softeners for the Treatment of Eczema in Children. PLoS Med 8(2): e1000395. doi:10.1371/journal.pmed.1000395

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000395

CONTACT:

Dr Kim Thomas
University of Nottingham
Centre of Evidence Based Dermatology
King's Meadow Campus
Nottingham, Nottinghamshire NG7 2NR
United Kingdom
01158468632
kim.thomas@nottingham.ac.uk

Or

Professor Hywel Williams
0115 8231048
hywel.williams@nottingham.ac.uk



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