This release is available in French.
Montreal May 5, 2011 – Children whose mother or father is affected by bipolar disorder may need to keep their stress levels in check. A new international study, led by Concordia University, suggests the stress hormone cortisol is a key player in the mood disorder. The findings published in Psychological Medicine, are the first to show that cortisol is elevated more readily in these children in response to the stressors of normal everyday life.
"Previous research has shown that children of parents with bipolar disorder are four times as likely to develop mood disorders as those from parents without the condition," says senior author Mark Ellenbogen, Canada Research Chair in Developmental Psychopathology at Concordia University and a member of the Centre for Research in Human Development. "The goal of our study was to determine how this is happening."
Cortisol, the telltale hormone
Ellenbogen and colleagues had previously shown that cortisol levels in children with a parent affected by bipolar disorder were higher than kids whose parents were unaffected by the condition. The current study measured cortisol levels in these same individuals, now in late adolescence and early adulthood, as well as chronic and episodic stress. When exposed to either type of stress, children of parents with bipolar disorder showed a greater increase in cortisol than those of parents without the disorder.
"Our study demonstrates that affected children are biologically more sensitive to the experience of stress in their natural and normal environment compared to their peers," says Ellenbogen. "This higher reactivity to stress might be one explanation of why these offspring end up developing disorders and is a clear risk factor to becoming ill later on."
"We think we might be beginning to understand where we can intervene to actually prevent this increased sensitivity from developing," continues Ellenbogen. "We believe this sensitivity develops during childhood and our suspicion is that if you could teach both parents and their offspring on how to cope with stress, how to deal with problems before they turn into larger significant stressors and difficulties, this would have a profound impact."
Cortisol is a hormone that is produced by the body in response to anxiety and researchers use cortisol to challenge the biological response to stress.
About bipolar disorder:
Bipolar disorder, which is also known as manic depression, is a treatable illness marked by extreme changes in mood, thought, energy and behavior. Bipolar disorder is also known as manic depression because a person's mood can alternate between mania (highs) and depression (lows). These changes in mood, or "mood swings," can last for hours, days, weeks or months.
Partners in research:
This work was supported by the Canadian Institutes of Health Research, the Social Sciences and Humanities Research Council of Canada and the Fonds du Québec en Recherche sur la Société de la Culture.
About the study:
The paper, "Sensitivity to stress among the offspring of parents with bipolar disorder: a study of daytime cortisol levels," was co-authored by C. S. Ostiguy, M. A. Ellenbogen of Concordia University; C.-D. Walker of the Douglas Hospital Research Centre and McGill University; E. F. Walker of Emory University; S. Hodgins of King's College London, Heidelberg University and the Université de Montréal.
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