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PUBLIC RELEASE DATE:
15-May-2011

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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
@FoxChaseCancer

Researchers examine procedure utilization trends in patients with clinically localized renal masses

WASHINGTON, D.C. (May 15, 2011)--New techniques in science and technology allow the medical community to continually improve patient care and experience, but as these new procedures are introduced, physicians must closely consider the relative risks and benefits for each patient. Laparoscopic surgery offers the short-term benefits of smaller incisions, shorter hospital stays, and less pain during recovery, but are there negative consequences in the long run for some patients? Certain groups of patients, like those with localized renal masses, may be more appropriately treated through surgical techniques that focus on preserving as much functional kidney as possible--especially since emerging data suggests that a loss of kidney function can lead to higher long-term risks of morbidity and mortality.

A new study to be presented by researchers from Fox Chase Cancer Center on Saturday, May 14, 2011, at the AUA 2011 Annual Meeting, examines whether the rapid adoption of minimally invasive techniques on the national level has had a negative impact on utilization rates of partial nephrectomy for patients with clinically localized renal masses.

"The AUA guidelines for localized renal masses recommend that kidney preservation is paramount when treating localized masses, but the rise of the number of partial nephrectomies--procedures that remove only part of a person's kidney--over time is lower than expected," says Marc Smaldone, M.D., urologic oncology fellow and lead author on the study. "As patient care evolves over time, we would expect to see the number of kidney preserving procedures increasing. Unfortunately, our results demonstrate that radical nephrectomy rates have remained consistent, which may be due to the preferential adoption of laparoscopic nephrectomy over partial nephrectomy in community practice."

When treating a patient with a localized renal mass, doctors have many surgical options. In radical procedures, surgeons remove the entire kidney, while partial nephrectomy techniques focus specifically on tumor removal while preserving as much functional kidney as possible. Either procedure may be performed via an open procedure through a large incision or a minimally invasive (or laparoscopic) approach.

In their study, researchers at Fox Chase demonstrated a dramatic 58 percent decrease in the percentage of open radical nephrectomy procedures performed from 1995 to 2005. However, they also observed more than a two-fold increase in laparoscopic nephrectomies in comparison to kidney sparing procedures over the same time period. These results suggest that more urologists are opting for laparoscopic nephrectomy, which may be due to increased familiarity and technical ease over more complex open or laparoscopic kidney preserving procedures. As a result, there is not the expected increase in the number of kidney preserving operations being performed, and more patients than necessary are being exposed to the adverse long-term consequences of chronic renal insufficiency.

"Knowing what we do about the long-term risks associated with removing a person's kidney, such as higher rates of long-term morbidity, it is crucial that, as physicians, we are doing all we can to spare as much of the organ as possible," says Robert G. Uzzo, M.D., F.A.C.S., chairman of the department of surgery at Fox Chase and member of the AUA Guidelines Council. "In this study, we're seeing a preference for laparoscopic procedures when we should be seeing a preference for nephron-sparing procedures."

To investigate this issue, Fox Chase identified 6,716 patients who underwent surgery for clinically localized renal masses between 1995 and 2005, drawn from linked SEER-Medicare data. They then compared utilization rates over time of four differing surgical procedures: open radical nephrectomy (ORN), laparoscopic radical nephrectomy (LRN), open partial nephrectomy (OPN), and laparoscopic partial nephrectomy (LPN). Their results demonstrate that over the ten-year period, utilization of nephron-sparing techniques--or partial nephrectomy--only increased by 15.5%, whereas 77% of patients with localized tumors were still managed with radical nephrectomy in 2005.

"Studies like these highlight that practice patterns evolve slowly over time, but more research is necessary," says Smaldone. "We now need to further investigate which types of institutions are performing specific procedure types and which patients have access to kidney preserving surgeries. These studies will ultimately help to ensure that we are providing all patients access to the best possible care."

"It is important that patients seek out care from physicians with expertise in kidney preservation techniques," adds Uzzo. "The benefits of laparoscopy don't offset the consequences of removing a patient's entire kidney if it's avoidable, and often, at most expert centers, a patient can receive the benefits of both through a laparoscopic partial nephrectomy."

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Co-authors on the study include Fox Chase researchers Alexander Kutikov, Daniel J. Canter, Brian L. Egleston, Rosalia Viterbo, Ervin Teper, David Y.T. Chen, Richard E. Greenberg, and Robert G. Uzzo.

Statistical support for this project was supported by Fox Chase Cancer's Keystone Program in Personalized Kidney Cancer Therapy. Established in 2008, this collaborative program brings researchers and clinicians from multiple disciplines together to investigate the biological mechanisms that lead to kidney cancer metastasis and to uncover the molecular signals that predict how an individual patient's kidney tumor will respond to therapies. Ultimately, the research supported by this privately-funded program will allow clinicians to optimize therapies for a given patient based on the unique molecular characteristics of his or her tumor.

Fox Chase Cancer Center is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation's first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974. Fox Chase researchers have won the highest awards in their fields, including two Nobel Prizes. Fox Chase physicians are also routinely recognized in national rankings, and the Center's nursing program has received the Magnet status for excellence three consecutive times. Today, Fox Chase conducts a broad array of nationally competitive basic, translational, and clinical research, with special programs in cancer prevention, detection, survivorship, and community outreach. For more information, visit Fox Chase's Web site at www.fccc.org or call 1-888-FOX CHASE or (1-888-369-2427).



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