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PUBLIC RELEASE DATE:
14-Jun-2011

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PLOS

Blood pressure changes are age-related

The main causes of increases in blood pressure over a lifetime are modifiable and could be targeted to help prevent cardiovascular disease: although high blood pressure sometimes has no obvious symptoms, this condition, which affects about a third of the adult UK and US populations, can lead to life-threatening heart attacks and stroke, so reducing blood pressure is very important for health.

As reported in this week's PLoS Medicine, a team of researchers, led by Andrew Wills from the Medical Research Council Unit for Lifelong Health and Ageing, University College London, used data from several UK studies in which blood pressure measurements in individuals were repeatedly taken over time and found that blood pressure changed at four phases throughout life: a rapid increase during adolescent growth; a gentler increase in early adulthood; a midlife acceleration (usually in the 40s); and finally for a period during late adulthood in which blood pressure increases slowly and then reverses.

The authors analysed the blood pressure measurements from a total of 30,372 individuals aged between 7 to 80 years and investigated the differences between the measurements in the studies done in the general population and in an occupational group.

Compared to the general population, the occupational group had lower average blood pressure, and midlife blood pressure acceleration appeared to begin later. Wider evidence suggests that this might in part reflect modifiable blood pressure-related factors such as diet and lifestyle that can vary with differences in social and economic circumstances. Furthermore, although at the beginning of adulthood women had lower blood pressure than men, an increased midlife acceleration (perhaps due to menopause-related effects on salt sensitivity) meant that later in life, men and women had similar average blood pressures. The findings also support the wide body of evidence that show a strong link between body mass index and blood pressure throughout life.

The authors say: "Whilst our study is unable to identify the key determinants of age-related increases in [blood pressure], further research should try to understand which factors affect this trajectory and when in the life course such factors exhibit most influence."

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Funding: A grant from the UK Medical Research Council (MRC) Population health sciences research network (PHSRN29) funded this research and the salary of AKW and EB. DK, RH, AA, GMT ([MRC] WBS U.1052.00.013.00003), FM (U.1052.00.013.00001,) and MB ([MRC] WBS U.1300.00.006) are supported by the UK MRC. RC is receiving support from the HALCyon programme funded by the New Dynamics of Ageing (RES-353-25-0001). The UK MRC and the University of Bristol provide core funding for the MRC Centre of Causal Analyses in Translational Epidemiology where DAL works. MK is supported by the BUPA Foundation, UK; the National Heart, Lung, and Blood Institute (R01HL036310-20A2) and the National Institute on Aging, NIH, US; the Academy of Finland, Finland; and the EU New OSH ERA Research Programme. The UK MRC, the Wellcome Trust and the University of Bristol provide core funding support for ALSPAC. The West of Scotland Twenty-07 Study is funded by the UK Medical Research Council (WBS U.1300.80.001.00001) and the data were originally collected by the MRC Social and Public Health Sciences Unit. The UK MRC provides funding for the NSHD. The Caerphilly Prospective Study was undertaken by the former MRC Epidemiology Unit (South Wales), and the Department of Social Medicine, University of Bristol, acts as the data custodian. The UK MRC and University of Southampton have been the principal funders of the Hertfordshire ageing study. The Whitehall II cohort receives programme support from the MRC, the British Heart Foundation, the National Institute of Aging, the National Heart, Lung, and Blood Institute, and the MacArthur Foundation. The views expressed in this paper are those of the authors and not necessarily those of any funding body or others whose support is acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Citation: Wills AK, Lawlor DA, Matthews FE, Aihie Sayer A, Bakra E, et al. (2011) Life Course Trajectories of Systolic Blood Pressure Using Longitudinal Data from Eight UK Cohorts. PLoS Med 8(6): e1000440. doi:10.1371/journal.pmed.1000440

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000440

CONTACT:

Dr. Andrew Wills

MRC Unit for Lifelong Health and Ageing

University College London
Epidemiology and Public Health
33 Bedford Place
London WC1B5JU
United Kingdom
02076705726
a.wills@nshd.mrc.ac.uk



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