[ Back to EurekAlert! ] Public release date: 20-Jul-2011
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Contact: Anne McMillin
amcmillin@medicine.nevada.edu
University of Nevada, Reno

Nevada School of Medicine researcher finds caffeine consumption, female infertility link

RENO, Nev. Caffeine reduces muscle activity in the Fallopian tubes that carry eggs from a woman's ovaries to her womb. "Our experiments were conducted in mice, but this finding goes a long way towards explaining why drinking caffeinated drinks can reduce a woman's chance of becoming pregnant," says Sean Ward, professor of physiology and cell biology, at the University of Nevada School of Medicine, who conducted the study.

Ward's study was recently published in the British Journal of Pharmacology.

Human eggs are microscopically small, but need to travel to a woman's womb if she is going to have a successful pregnancy. Although the process is essential for a successful pregnancy, scientists know little about how eggs move through the muscular Fallopian tubes. It was generally assumed that tiny hair-like projections, called cilia, in the lining of the tubes, waft eggs along assisted by muscle contractions in the tube walls.

By studying tubes from mice, Ward and his team discovered that caffeine stops the actions of specialized pacemaker cells in the wall of the tubes. These cells coordinate tube contractions so that when they are inhibited, eggs can't move down the tubes. In fact these muscle contractions play a bigger role than the beating cilia in moving the egg towards the womb.

"This provides an intriguing explanation as to why women with high caffeine consumption often take longer to conceive than women who do not consume caffeine," said Ward.

Discovering the link between caffeine consumption and reduced fertility has benefits.

"As well as potentially helping women who are finding it difficult to get pregnant, a better understanding of the way Fallopian tubes work will help doctors treat pelvic inflammation and sexually-transmitted disease more successfully," said Ward.

It could also increase our understanding of what causes ectopic pregnancy, an extremely painful and potentially life-threatening situation in which embryos get stuck and start developing inside a woman's Fallopian tube.

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Media wishing to receive a PDF of this article from the British Journal of Pharmacology may contact: healthnews@wiley.com

As the state's only public medical school, the University of Nevada School of Medicine has been a leader in health care, medical education, and research in Nevada since 1969. The School of Medicine encompasses 16 clinical departments including family medicine, pediatrics, obstetrics and gynecology, internal medicine, surgery, and psychiatry and behavioral sciences, and five nationally-recognized departments in basic science. The doctors of University Health System, the school's clinical practice, offer care in more than 40 medical specialties and subspecialties with seven physician offices in the Reno area and seven in Las Vegas. The school is dedicated to a best-practice approach to medicine and is committed to addressing the health needs of Nevada now and in the future. For more information, please visit www.medicine.nevada.edu.



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