Peptides and proteins have long been an attractive class of drug candidates because of their natural involvement in cellular processes and fewer potential side effects. Dr. Andrei Yudin, Professor, Department of Chemistry, University of Toronto, has developed a new and effective process that makes linear peptides circular, which allows these molecules, called macrocycles, to enter cells more effectively and increase their stability compared to linear peptides. Given their advantageous properties, macrocycles are emerging as a new class of molecules with potential in drug development.
Dr. Yudin and his group's unique ability to efficiently cyclize a broad range of linear peptides provides the opportunity to build a diverse library of macrocycles as possible drug candidates. The Yudin group will build a targeted library of macrocyles and test it for important properties including cell permeability and stability. This compound library will enable researchers and pharmaceutical organizations to screen for biologically active structures against disease-relevant targets, with the ultimate goal of identifying novel therapeutic macrocycles for new drug development. Dr. Yudin will be working closely with pharmaceutical companies to build a library that will meet the needs of industry.
"This work has the potential to help change the face of drug development and expand the options available in the creation of new therapeutics," commented Dr. Mark Poznansky, President and CEO, OGI. "Dr. Yudin and his group are clearly poised to be key influencers in this area."
"We are delighted to receive the investment from OGI as we move closer to commercialization," commented Dr. Yudin. "Our initial endeavour to generate a library of compounds is based around fundamental properties of drug-like compounds. Our method of cyclizing peptides will allow us to grow our inventory of compounds to eventually compete on a global scale in this emerging area of constrained peptides."
In addition to the PBDF funding, the technology has received investment by MaRS Innovation, the commercialization agent for 16 Ontario-based research institutions.
"We see significant appetite in the market for viable discovery platforms for peptide based therapeutics. It is important that Dr. Yudin receives appropriate support at this early stage to maximize the potential of this work," commented Dr. Rafi Hofstein, President and CEO, MaRS Innovation. "At MaRS Innovation, we work with many of the Province's leading researchers to convert great science into commercial opportunities."
U of T's Innovations and Partnerships Office (IPO) is working in collaboration with MI and Dr. Yudin to commercialize his novel platform technology.
"The University of Toronto is grateful to the Ontario Genomics Institute for this investment in our research," said Dr. Peter Lewis, Associate Vice President, Research at U of T and Acting Assistant Vice President, IPO. "The PBDF award will be vital in helping U of T and MaRS Innovation to bring Dr. Yudin's innovation to the marketplace. Just as importantly, OGI's support will assist greatly in enabling Dr. Yudin's work to make a strong and positive impact on global society."
OGI's PBDF program invests in opportunities — based in genomics, proteomics or associated technologies — that fall in the proof-of-principle (validation) phase of research and that have the short-term potential to secure a significant next step towards the marketplace. Previous recipients have included Ontario universities, research institutes and companies.
The Ontario Genomics Institute (OGI) is a private, not-for-profit corporation focused on using world-class research to create strategic genomics resources and accelerate Ontario's development of a globally-competitive life sciences sector. Through its relationship with Genome Canada, the Ontario Ministry of Research and Innovation (MRI), and other private and public sector partners, OGI works to: identify, attract and support investment in Ontario-led genomics research; catalyze access to and the impact of genomics resources; and, raise the visibility of genomics as well as its impact and associated issues. For more information on OGI, please visit www.OntarioGenomics.ca
OGI media enquiries: Alastair Harris-Cartwright, Corporate Communications Manager, T: +1 (416) 673-6582.
PBDF information: Rhonda Tannenbaum, Director of Business Development, T: +1 (416) 673-6586
About MaRS Innovation
MaRS Innovation provides an integrated commercialization platform that harnesses the economic potential of the exceptional discovery pipeline of 16 leading Toronto academic institutions. MaRS Innovation is a non-profit organization with an independent industry-led Board of Directors, funded through the Government of Canada's Networks of Centres of Excellence and contributions of its member institutions. Designed to enhance the commercial output of Toronto's outstanding scientific research cluster, MaRS Innovation will make a significant contribution to Canada's economic outlook and the quality of life for Canadians and others around the world. MaRS Innovation will advance commercialization through industry partnerships, licensing and company creation. The MaRS Innovation mission is to put Canada on the global innovation stage, by better connection research with industry and strengthening Canada's competitive capacity in knowledge based business – in short, to launch and new generation of robust, high-growth Canadian companies that will become global market leaders.
For more information about the Yudin Group: http://www.chem.utoronto.ca/staff/YUDIN/yudinsgroup.html
For information about MaRS Innovation: www.marsinnovation.com
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