Researchers from Mount Sinai School of Medicine have for the first time used several imaging techniques to prove the efficacy of a promising new treatment for atherosclerosis—the build-up of plaque in artery walls that can lead to a heart attack. Using positron-emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI), the research team showed that dalcetrapib, a novel treatment for atherosclerosis, prevented the progression of disease and reduced vascular inflammation over 24 months. The data are published in the September 12 issue of The Lancet.
The dal-PLAQUE study is the longest placebo-controlled, active-drug MRI study to date, and the first to use a variety of noninvasive imaging techniques to visualize arterial plaque. In this Phase IIB, double-blind, multicenter trial, Mount Sinai researchers evaluated 130 study participants with atherosclerosis who were randomized to receive dalcetrapib or placebo for 24 months. To determine the efficacy of dalcetrapib, the team used MRI to analyze plaque progression in the arterial wall and PET/CT to assess arterial inflammation. The images showed that dalcetrapib significantly reduced atherosclerotic disease progression and inflammation.
"This milestone study shows that MRI and PET/CT are highly useful in assessing the safety and efficacy of dalcetrapib, and that this novel therapy may address a significantly unmet need in cardiovascular disease," said Zahi A. Fayad, PhD, Professor of Radiology and Medicine in the Division of Cardiology, and the Director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine, and lead author on the study. "We are excited about the results obtained in this trial, which could have a great impact on the treatment of patients with cardiovascular disease."
Lowering of the so-called bad cholesterol (low-density lipoprotein) through statin use, is a highly effective method of improving cardiovascular outcome in a broad range of patients. However, despite optimal use, significant risk remains. Dalcetrapib is part of a class of drugs called cholesteryl ester transfer protein inhibitors that raise high-density lipoprotein (HDL) commonly known as "good" cholesterol. Research has shown that raising HDL cholesterol may reduce coronary artery disease risk. In the dal-PLAQUE study, patients who received dalcetrapib saw a 31 percent increase in HDL cholesterol levels, as examined through MRI. The PET/CT scans showed that inflammation levels in the carotid artery of patients taking dalcetrapib were significantly reduced, yet stayed the same in the placebo group.
"Considering the concerns surrounding this class of drugs, MRI and PET/CT imaging are valuable biomarkers for assessing safety and efficacy," said Dr. Fayad. "The first drug in this class, torcetrapib, effectively increased HDL cholesterol but caused a significant increase in mortality due to vascular inflammation. Through noninvasive imaging, we were able to determine that the inflammation associated with torcetrapib was not found in dalcetrapib. The success of this trial indicates that noninvasive imaging may be a critical tool for evaluating other investigational treatments for heart disease as well."
As a leader in cardiovascular medicine and imaging, Mount Sinai is establishing a center that will use state of the art imaging technology to help treat and prevent atherosclerosis, heart attack, and heart failure. In collaboration with the Mount Sinai Cardiovascular Institute and Mount Sinai Heart, the new Translational and Molecular Imaging Institute will continue to innovate, validate and translate new tools for the improvements of patients care.
"Cardiovascular disease impacts millions of people, and costs billions of dollars each year in the United States alone," said Valentin Fuster, MD, PhD, Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health at The Mount Sinai Medical Center. "As demonstrated in the dal-PLAQUE study, Dr. Fayad has brought Mount Sinai to the forefront of using noninvasive imaging to help study, prevent, and treat heart disease. We look forward to using MRI and PET/CT in future clinical trials."
The centers that participated in the dal-PLAQUE trial include: Baylor College of Medicine, Houston; Cardiovascular Imaging Technologies, Kansas; University of Minnesota; The Mount Sinai Medical Center, New York; University of Washington School of Medicine, Seattle; Jacksonville Center for Clinical Research; Iredell Internal Medicine; Sterling Research Group; Metabolic and Atherosclerosis Research Center, Cincinnati; William Beaumont Hospital Health Center; Montreal Heart Institute.
Dr. Fayad receives financial compensation as a scientific advisory board member for F. Hoffman-La Roche Ltd, the sponsor of this study.
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