More than other drugs, injected meth is associated with an increased risk of attempted suicide

December 22, 2011 -- The dire physical and mental health effects of injecting methamphetamine are well known, but there's been little research about suicidal behavior and injecting meth. In a recent study, researchers at Columbia University's Mailman School of Public Health and the University of British Columbia found that drug users who inject methamphetamine had an 80% greater risk of attempting suicide than drug users who inject other substances.

Although the causal pathway between injecting methamphetamine and suicidal behavior requires further investigation, study authors suggest that it likely involves a combination of neurobiological, social, and structural mechanisms, at least in the population studied.

The study results are published in the December issue of Drug and Alcohol Dependence.

"Compared to other injection drug users, it is possible that methamphetamine users are more isolated and have poorer social support systems," said lead author Brandon Marshall, PhD, a postdoctoral fellow at the Mailman School of Public Health and research coordinator for the Urban Health Research Initiative in British Colombia. "The high rate of attempted suicide observed in this study suggests that suicide prevention efforts should be an integral part of substance abuse treatment programs," said Dr. Marshall. "In addition, people who inject methamphetamine but are not in treatment would likely benefit from improved suicide risk assessment and other mental health support services within health care settings."

The Vancouver Injection Drug Users Study is part of the ongoing British Columbia Centre for Excellence in HIV/AIDS' Urban Health Research Initiative, which focuses on the effects of substance use, infectious diseases, and the urban environment on the health of urban populations. Vancouver's Downtown Eastside is known as a center for illicit drug use, and fatalities from drug overdoses and drug-related violence are common. A large outbreak of HIV infection reported there in 1997 was among the fastest spreading HIV epidemics in the developed world.

Participation in the seven-year study, which ended in May 2008, was through word of mouth, street outreach, and referrals and included an interviewer-administered questionnaire on sociodemographic characteristics, drug use, treatment utilization, and HIV risk behaviors. The researchers evaluated 1,873 participants whose median age was 31, while 36.2% of participants were female, and 32.1% were of Aboriginal ancestry. In total, 8% percent of study participants reported a suicide attempt.

"This is one of North America's largest cohorts of injection drug users, and the research is among the first longitudinal studies to examine attempts of suicide by injection drug users," said Dr. Marshall. "Most of these 5,000 users are concentrated in a very small neighborhood, making it a logical environment for this type of study. Because our study is one of the main points of access to health care for this population, this is a very well utilized study with a high rate of follow-up."

Dr. Marshall and colleagues also discovered that infrequent methamphetamine injection was a predictor of attempting suicide, while frequent methamphetamine injection was associated with the greatest risk of attempting suicide.

The study was funded by the National Institutes of Health and the Canadian Institutes of Health Research.

Founded in 1922 as one of the first three public health academies in the nation, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 300 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,000 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including the International Center for AIDS Care and Treatment Programs (ICAP), the National Center for Disaster Preparedness, and the Center for Infection and Immunity. For more information, please visit www.mailman.columbia.edu

The University of British Columbia (UBC) is one of North America's largest public research and teaching institutions, and one of only two Canadian institutions consistently ranked among the world's 40 best universities. Surrounded by the beauty of the Canadian West, it is a place that inspires bold, new ways of thinking that have helped make it a national leader in areas as diverse as community service learning, sustainability and research commercialization. UBC offers more than 55,000 students a range of innovative programs and attracts $550 million per year in research funding from government, non-profit organizations and industry through more than 7,000 grants.