The combination of bortezomib, cyclophosphamide, and dexamethasone (CyBorD, or CVD) is a recently discovered but already widely used MM treatment regimen that produces rapid and profound responses. Because of its success in MM, recent investigations have explored the use of this regimen as a potential therapy for AL amyloidosis, since those with the disease have few treatment options. Currently, the most effective treatment for AL amyloidosis is high-dose melphalan and autologous stem cell transplant; however, most patients are ineligible for this aggressive and difficult to tolerate approach due to organ damage common in patients with the disease.
Fortunately for AL amyloidosis patients, there is hope for a better treatment. Each of the studies summarized below conclude that treatment with the novel CyBorD/CVD regimen can lead to complete hematologic response and may allow AL amyloidosis patients to become eligible for stem cell transplants and live longer, higher quality lives.
STUDY 1: Cyclophosphamide-Bortezomib-Dexamethasone (CYBORD) Produces Rapid and Complete Hematological Response In Patients with AL Amyloidosis
First Author: Joseph Mikhael, MD, Mayo Clinic, Scottsdale, AZ
Background
- Retrospective analysis of 17 patients with confirmed and symptomatic AL amyloidosis treated with CyBorD prior to autologous stem cell transplant (ASCT), as an alternative to high-dose therapy for those deemed ineligible, and as salvage for those with prior therapy
Results
- 94% hematologic response rate observed in patients
- Three patients originally not eligible for ASCT became eligible after treatment
Conclusion
- CyBorD produces rapid and complete hematologic responses in the majority of patients with AL amyloidosis regardless of previous treatment or ASCT candidacy and is well tolerated with few side effects. In addition, results demonstrate that the regimen may also allow ASCT non-eligible patients to become eligible after treatment.
STUDY 2: Cyclophosphamide, Bortezomib and Dexamethasone Therapy in AL Amyloidosis is Associated with High Clonal Response Rates and Prolonged ProgressionFree Survival
First Author: Christopher Venner, MD, National Amyloidosis Centre, University College London Medical School, London, United Kingdom
Background
- Retrospective analysis of 43 patients with AL amyloidosis treated with CVD upfront or at relapse
Results
- 81.4% hematologic response rate observed in patients
Conclusion
- CVD is a highly effective combination for the treatment of AL amyloidosis with high hematologic responses. In addition, rapid improvement in organ function was observed and functional organ improvement may potentially allow deferred stem cell transplant in previously ineligible patients due to increased organ response.
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The American Society of Hematology is the world's largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology. The official journal of ASH is Blood, the most cited peer-reviewed publication in the field, which is available weekly in print and online.Journal
Blood