[ Back to EurekAlert! ] Public release date: 21-Mar-2012
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Contact: Alexandra Bassil
a.bassil@miami.edu
305-284-1092
University of Miami

Stress management for breast cancer patients may affect disease course

University of Miami study and breast cancer's course

CORAL GABLES, FL (March 21, 2012)—A team of researchers led by Michael H. Antoni, director of the Center for Psycho-Oncology Research at the University of Miami (UM) has shown that a stress management program tailored to women with breast cancer can alter tumor-promoting processes at the molecular level. The new study recently published in the journal Biological Psychiatry is one of the first to link psychological intervention with genetic expression in cancer patients.

According to the study, the group-based Cognitive-Behavioral Stress Management (CBSM) intervention designed by the researchers affects which genes in the cells of the immune system are turned on and off, in ways that may facilitate better recovery during treatment for breast cancer, explains Antoni, professor of Psychology in the College of Arts and Sciences, and professor of Psychiatry and Behavioral Sciences and program leader of Biobehavioral Oncology at the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.

"For the women in the CBSM groups, there was better psychological adaptation to the whole process of going through treatment for breast cancer and there were physiological changes that indicated that the women were recovering better," Antoni says. "The results suggest that the stress management intervention mitigates the influence of the stress of cancer treatment and promotes recovery over the first year."

Previous research has shown that during times of adversity, our nervous and endocrine systems send signals to the immune system, which defends us from disease. In response, our body activates specific genes inside immune cells called white blood cells or leukocytes, Antoni explains.

"For the women that participated in the intervention groups, the genes that signal the production of molecules associated with a healthy immune response, such as type I interferon were up-regulated—meaning they were producing more of these substances, compared to levels seen in the control group," Antoni says. "At the same time, the genes responsible for the production of substances involved in cancer progression, such as pro-inflammatory cytokines, chemokines and matrix metalloproteinases were down-regulated."

CBSM is a 10-week group-based program developed at UM that combines relaxation, imagery and deep breathing, along with cognitive behavior therapy, which is designed to help patients reduce bodily tension, change the way they deal with intrusive stressful thoughts, decrease negative moods, and improve their interpersonal communication skills. In the study, 79 women undergoing primary treatment for stage 0-III breast cancer were randomized into a 10 week CBSM program or a psychoeducational control group in the weeks following surgery. Six month and 12-month follow up assessments were conducted.

"You essentially have this timeframe in a woman's life where she is getting diagnosed with breast cancer, followed by surgery, then chemotherapy or radiation, and it's very stressful," Antoni says. "This can be an emotionally and physically exhausting period offering little opportunity for recovery. If stress affects the immune system in a negative way, then their recovery could be slowed down and those patients taking longer to recover may be at risk for poorer health outcomes. Conversely, if stress management intervention can reduce the impact of stress on the immune system then recovery may be hastened."

The research team plans to follow the women in this cohort to see if CBSM intervention and its effects on leukocyte gene expression are predictive of reoccurrence and/or long term health outcomes.

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The study titled "Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics" was funded by the National Cancer Institute and The Pap Corps, Champions for Cancer Research.

Co-authors are Susan K. Lutgendorf, professor of Psychology, University of Iowa and Holden Comprehensive Cancer Center; Bonnie Blomberg professor of Microbiology and Immunology, and member of the Tumor Immunology and Biobehavioral Oncology programs at Sylvester; Charles S. Carver, professor and director of the adult program in the Department of Psychology and member of the Biobehavioral Oncology program at Sylvester; Suzanne Lechner, research assistant professor of Psychiatry and Behavioral Sciences and member of the Biobehavioral Oncology program at Sylvester; Alain Diaz, research associate, Department of Microbiology and Immunology, Miller School of Medicine; Jamie Stagl, graduate student in the Clinical Health Psychology program at UM; Jesusa M.G. Arevalo, research associate, UCLA School of Medicine, and Steven W. Cole, professor of Medicine, UCLA Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and Norman Cousins Center for Psychoneuroimmunology.

The University of Miami's mission is to educate and nurture students, to create knowledge, and to provide service to our community and beyond. Committed to excellence and proud of the diversity of our University family, we strive to develop future leaders of our nation and the world. www.miami.edu



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