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PUBLIC RELEASE DATE:
29-Apr-2012

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Contact: Dr Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
@biomedcentral

Breastfeeding is associated with a healthy infant gut

Early colonization of the gut by microbes in infants is critical for development of their intestinal tract and in immune development. A new study, published in BioMed Central's open access journal Genome Biology, shows that differences in bacterial colonization of formula-fed and breast-fed babies leads to changes in the infant's expression of genes involved in the immune system, and in defense against pathogens.

The health of individuals can be influenced by the diversity of microbes colonizing the gut, and microbial colonization can be especially important in regulating both intestinal and immune development in infants. However, little is known about the potential interactions between the host's health at a molecular level, their gut microbes, and diet.

The human intestine is lined by epithelial cells that process nutrients and provide the first line of defense against food antigens and pathogens. Approximately one-sixth of intestinal epithelial cells are shed every day into feces, providing a non-invasive picture of what is going on inside the gut.

In this study, the authors used transcriptome analysis to compare the intestines of three month old exclusively breast-fed or formula-fed infants, and relate this to their gut microbes. Transcriptome analysis looks at the small percentage of the genetic code that is transcribed into RNA molecules and is a measure of what genes are actively making proteins. Concurrently the microbes (microbiome) were identified by genetic analysis.

The results showed that the breast-fed babies had a wider range of microbes in their gut than the formula-fed infants but that their immune systems had developed to cope.

Robert Chapkin from the Texas A&M University, who led this multi-centre study, explained, "While we found that the microbiome of breast-fed infants is significantly enriched in genes associated with 'virulence', including resistance to antibiotics and toxic compounds, we also found a correlation between bacterial pathogenicity and the expression of host genes associated with immune and defense mechanisms."

He continued, "Our findings suggest that human milk promotes the beneficial crosstalk between the immune system and microbe population in the gut, and maintains intestinal stability."

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Media Contact

Dr Hilary Glover
Scientific Press Officer, BioMed Central
Tel: +44 (0) 20 3192 2370
Mob: +44 (0) 778 698 1967
Email: hilary.glover@biomedcentral.com

Notes to Editors

1. A Metagenomic Study of Diet-Dependent Interaction Between Gut Microbiota and Host in Infants Reveals Differences in Immune Response Scott Schwartz, Iddo Friedberg, Ivan V Ivanov, Laurie A Davidson, Jennifer S Goldsby, David B Dahl, Damir Herman, Mei Wang, Sharon M Donovan and Robert Chapkin Genome Biology (in press)

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request on the day of publication.

2. Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.



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