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Contact: Karen Astle
karen.astle@heart.org
214-706-1392
American Heart Association

Low vitamin D in diet increases stroke risk in Japanese-Americans

Japanese-American men who did not eat foods rich in vitamin D had a higher risk of stroke later in life, according to results of a 34-year study reported in Stroke, an American Heart Association journal.

"Our study confirms that eating foods rich in vitamin D might be beneficial for stroke prevention," said Gotaro Kojima, M.D., lead author of the study and geriatric medicine fellow at the John A. Burns School of Medicine at the University of Hawaii in Honolulu.

Vitamin D is an essential nutrient that helps prevent rickets in children and severe bone loss in adults, and researchers believe it has the potential to lower the risk of a host of diseases including cancer and diabetes.

Sunlight is generally the greatest source, but synthesizing vitamin D from the sun gets more difficult as we age, Kojima said, so older people are advised to eat more foods rich in vitamin D or take supplements. Good sources include fortified milk and breakfast cereals, fatty fish and egg yolks.

Study participants included 7,385 Japanese-American men living on Oahu, Hawaii. All were participants of the Kuakini Honolulu Heart Program, a study of stroke and coronary heart disease in Japanese-American men that began in 1965 which was conducted at the Kuakini Medical Center.

Participants were 45 to 68 years old in the mid- to late-1960s when they were first examined and interviewed about what they had eaten in the previous 24 hours. Food models and serving utensils were used to help participants determine their portions accurately.

Researchers separated the participants into four groups of approximately 1,845 each depending on how much vitamin D they had consumed. They then analyzed their records through 1999, roughly 34 years after the initial exams, to determine the incidence of stroke. New strokes occurred in 960 men during the follow up period.

Researchers calculated risk while adjusting for age, total calorie intake, body-mass index, hypertension, diabetes, cigarette smoking, physical activity, cholesterol levels and alcohol intake. Men who consumed the least dietary vitamin D had a 22 percent higher risk of stroke and a 27 percent increase risk of ischemic (blood-clot related) stroke compared to those consuming the highest levels of vitamin D. There was no difference for hemorrhagic stroke.

Stroke ranks fourth among the leading causes of death in the United States. New or recurrent strokes strike about 795,000 Americans annually. Ischemic strokes account for 87 percent of all strokes, and 10 percent are from an intracranial hemorrhage (bleeding in the brain). The remaining 3 percent result from bleeding in the subarachnoid space between the brain and the tissues covering it.

Kojima said it is unclear whether the study results could be applied to different ethnic groups or to women.

While previous studies focused on blood concentrations of vitamin D, this investigation used dietary intake.

###

Co-authors are Christina Bell, M.D.; Robert D. Abbott, Ph.D.; Lenore J. Launer, Ph.D.; Randi Chen, M.S.; Heather Motonaga, M.D.; G. Webster Ross, M.D.; J. David Curb, M.D.; and Kamal Masaki, M.D. Author disclosures are on the manuscript.

The National Heart, Lung, and Blood Institute and the National Institute on Aging funded the study.

The American Heart Association offers information on Diet and Lifestyle Recommendations. For information on stroke visit strokeassociation.org.

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www.heart.org/corporatefunding.

NR12 1079 (Stroke/Kojima)



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