Arlington, Va. -- A new compound created from a rich source in vegetables including broccoli and brussel sprouts has been developed to combat triple-negative breast cancer (TNBC). This research is being presented at the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Chicago, Ill., on Oct. 14 - 18, during Breast Cancer Awareness Month.
TNBC accounts for approximately 15-20 percent of all breast cancer cases in the U.S. It is one of the most aggressive forms of breast cancer; it grows faster, spreads to other parts of the body earlier, is harder to detect on a mammogram and recurs more often.
Mandip Sachdeva, Ph.D. and Chandraiah Godugu, P.h.D. from Florida A&M University, in collaboration with Stephen Safe, Ph.D., from Texas A&M University, have evaluated the activity of novel C-substituted diindolylmethane (C-DIM) derivatives and demonstrated that they have superior anticancer activities. Sachdeva's study reveals that these synthetic compounds derived from diindolylmethane (DIM), commonly found in various types of cruciferous vegetables, can be used to treat several types of cancer, including triple-negative breast cancer. C-DIMs are also being investigated for their cancer prevention activity.
"Targeted treatment options for TNBC are limited; current treatments, such as infusions, result in poor patient compliance and increased toxicity," said Sachdeva. "We are confident that the compounds we are currently working with are an effective treatment for triple-negative breast cancer. These compounds are safer for the patient than current treatments available."
In contrast to existing anticancer drugs, the diindolylmethane compounds are orally active, so they could be available to patients in pill form and safe to take daily. When taken in combination with existing anticancer drugs, the diindolylmethane compounds can effectively decrease the number of treatments a patient receives.
The 2012 AAPS Annual Meeting and Exposition aims to improve global health through advances in pharmaceutical sciences. The meeting features more than 90 programming sessions, including more than 50 symposia and roundtables.
AAPS is pleased to announce that our smartphone application is available at the 2012 AAPS Annual Meeting and Exposition. This application can assist meeting attendees with anything and everything they need to navigate the conference at their fingertips.
This work was supported by DOD grant number W81XWH-11-1-0211 and NIMHD P20 grant, 1P20MD006738-01.
Editor's Note: All press must provide press credentials to attend this meeting. The deadline for online media registration is Oct. 5. After that date, media must register on-site. For media registration, please contact Kimberly Brown at BrownK@aaps.org or (703) 248-4772. To schedule an interview with Mandip Sachdeva or for any other press inquiry, please contact Hillarie Turner or Dana Korsen at firstname.lastname@example.org or 202-296-2002.
The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 11,000 members employed in academia, industry, government and other research institutes worldwide. Founded in 1986, AAPS provides a dynamic international forum for the exchange of knowledge among scientists to serve the public and enhance their contributions to health. AAPS offers timely scientific programs, on-going education, information resources, opportunities for networking, and professional development. For more information, please visit www.aaps.org. Follow us on Twitter @AAPSComms; official Twitter hashtag for the meeting is: #AAPS2012.