[ Back to EurekAlert! ] Public release date: 19-Nov-2012
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

A code of silence in acute myeloid leukemia

The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the DNA alter gene expression. In a study published in the Journal of Clinical Investigation, researchers led by Daniel Tenen at Beth Israel Deaconess Medical Center found that a transcriptional regulator known as C/EBPG was highly expressed in a subset of AML samples that had an epigenetically silenced C/EBPA gene. By blocking the epigenetic modification of C/EBPA, Tenen and colleagues found that they could reduce C/EBPG and restore normal myeloid blood cells. This study suggests that targeting the balance of C/EBPG and C/EBPA could represent a new therapeutic approach in the treatment of AML.

TITLE:
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia

AUTHOR CONTACT:
Daniel Tenen
Beth Israel Deaconess Medical Center, Boston, MA, USA
Phone: 617-735-2235; Fax: 617-735-2222; E-mail: dtenen@bidmc.harvard.edu

View this article at: http://www.jci.org/articles/view/65102?key=2caafbb63e0b6ae08fa7

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