[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:
19-Nov-2012

[ | E-mail ] Share Share

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
@jclinicalinvest

Immune cell migration is impeded in Huntington's disease

Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells as well. In this issue of the Journal of Clinical Investigation, researchers led by Paul Muchowski at the J. David Gladstone Institutes in San Franscisco examined the role of immune cells in HD. Immune cells known as microglia, which were isolated from the brains of HD mice, as well as immune cells from the peripheral blood were found to be defective in their ability to migrate. Interestingly, the immune cell defects were apparent prior to the onset of HD symptoms. This study suggests that changes in immune cell function may underlie some of the symptoms of HD.

###

TITLE:
Mutant huntingtin impairs immune cell migration in Huntington disease

AUTHOR CONTACT:
Paul Muchowski
J. David Gladstone Institutes, San Francisco, CA, USA
Phone: 415-734-2515; E-mail: pmuchowski@gladstone.ucsf.edu

View this article at: http://www.jci.org/articles/view/64484?key=ed9b525e3a43db3e13d8



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.