[ Back to EurekAlert! ] Public release date: 14-Feb-2013
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Contact: Elizabeth Powers
powerse@cshl.edu
415-422-4101
Cold Spring Harbor Laboratory

Bridges experimental and bioinformatics perspectives to delineate protein-DNA interactions

IMAGE: This is a computer-generated structural diagram showing the overall geometry of the Lac repressor protein binding to Lac operator DNA. (Generated using PyMOL software from the data in the Protein...

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One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. An Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein–DNA interactions.

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