Public Release:  Targeting T cells in rheumatoid arthritis

Journal of Clinical Investigation

Rheumatoid arthritis (RA) is an autoimmune disorder in which immune cells attack the joints, causing inflammation, swelling, and erosion. Specific sets of immune cells, known as T cells, are responsible for inducing disease. In this issue of the Journal of Clinical Investigation, researchers led by Harvey Cantor at Harvard University analyzed the contributions of different subsets of T cells to an RA-like condition in mice. Cantor and colleagues identified a subset of regulatory T cells (CD8+ Tregs) that can remove pathogenic T cell subsets and inhibit disease progression. Additionally, they identified small proteins that induced more CD8+ Tregs. These findings suggest that enhancing specific T cell subsets may be useful in combating RA and other autoimmune diseases.

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TITLE:

Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T-cells

AUTHOR CONTACT:

Harvey Cantor
Dana Farber Cancer Institute
Boston, MA, USA
Phone: 617-632-3348
Fax: 617-632-4630
E-mail: harvey_cantor@dfci.harvard.edu

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