(TORONTO, Canada - Feb. 13, 2013) - An international team of tropical medicine researchers have discovered a potential method for preventing low birth weight in babies born to pregnant women who are exposed to malaria. Low birth weight is the leading cause of infant death globally.
The findings of Malaria Impairs Placental Vascular Development, published today online ahead of print in Cell Host & Microbe, showed that the protein C5a and its receptor, C5aR, seem to control the blood vessel development in the mother's placenta. Without adequate blood vessels in the placenta, the baby's growth can't be sustained and the baby is born low birth weight.
"There are few things more important to the human species than healthy pregnancies, yet we have a poor understanding of what causes adverse birth outcomes such as prematurity or stillbirths", says principal investigator, Dr. Kevin Kain, Director, SAR Labs, Sandra Rotman Center for Global Health, University Health Network and the University of Toronto. "These studies focus on women in Africa who have malaria, but may provide a better understanding of why poor birth outcomes occur, and how we might prevent them, anywhere in the world."
Researchers determined that excessive activation of a complement protein C5 occurs in pregnant women with malaria and alters the ability of the placenta to grow blood vessels required to sustain the developing baby.
When C5a-C5aR was blocked in genetic models, researchers found it increased placental blood vessels and improved survival and growth of the fetus. They replicated the study using a drug that blocked C5a with the same results.
Dr. Kain's research is supported by Global Alliance to Prevent Prematurity and Stillbirth and Grand Challenges in Global Health: Preventing Preterm Birth Initiative, the Canadian Institutes of Health Research, and the Canada Research Chair program.
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University Health Network consists of Toronto General and Toronto Western Hospitals, the Princess Margaret Cancer Centre, and Toronto Rehabilitation Institute. The scope of research and complexity of cases at University Health Network has made it a national and international source for discovery, education and patient care. It has the largest hospital-based research program in Canada, with major research in cardiology, transplantation, neurosciences, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. University Health Network is a research hospital affiliated with the University of Toronto. www.uhn.ca