Public Release:  P&G Beauty & Grooming to present advancements in skin aging & stress sweat at AAD Meeting

Cutting-edge research inspires new innovations for Olay, Secret brands

Spectrum

Miami Beach, FL (March 1, 2013) - Research presented by P&G Beauty & Grooming scientists at the 71st Annual Meeting of the American Academy of Dermatology (AAD) examines skin care science from multiple perspectives, offering insights into new ingredient formulations, skin care regimens and more. P&G Beauty & Grooming has 22 studies on display, addressing innovative topics such as cellular bioenergetics, skin fatigue theory and scientific break-throughs in management of stress-related sweat.

"P&G Beauty & Grooming is thrilled to have nearly two dozen posters on display at AAD this year and looks forward to sharing our research and findings. Our team's hard work has, among others, informed innovations in skin energy research with the Olay brand and led to a deeper understanding of stress sweat, spurring Secret brand product development," said Phil Marchant, Global Scientific Communications Director with P&G Beauty & Grooming. "Innovation is at the core of our brands and P&G Beauty & Grooming scientists are proud to use this event to showcase our findings and collaborate with thought leaders in the field of dermatology."

The following research summaries are just a sample of the breakthroughs, findings and innovative science that P&G Beauty & Grooming will share at the AAD Annual Meeting:

Appearance of Uneven Facial Texture is Improved by a Facial Moisturizer Containing Cosmetic Ingredients that Boost Cellular Energy (P7051)

A complex of cosmetic ingredients (niacinamide, Pal-KTTKS and an olive oil derivative) has been shown to increase cellular energy molecules (ATP and NAD+/NADH) as well as cellular metabolism in aging skin cells in vitro. Additionally, the ingredients have been shown to affect skin structure and protect skin cells from oxidative damage in vitro. When dill extract was added to the complex, responses further improved. In the current study, P&G Beauty & Grooming evaluated a daily-use facial moisturizer formulation containing a complex of niacinamide, pal-KTTKS, an olive oil derivative and dill extract, compared to a controlled moisturizer, to assess the effects on the appearance of aging facial skin.

Study results indicated daily use of a cosmetic moisturizer containing niacinamide, Pal-KTTKS, an olive oil derivative and dill extract improved the appearance of uneven facial skin texture. Furthermore, the addition of dill extract to the complex boosted skin elasticity and firmness. These results suggest that daily use of moisturizer formulations containing ingredients related to skin energy can lead to an improved appearance of aging skin.

Impact of Oxidative Stress on Cellular Bioenergetics in Older Aged Fibroblasts: Ability of Niacinamide to Prevent and Restore Metabolic Pathway Efficiency and Energy Production (P7041)

The exposure of skin to environmental factors such as UV rays triggers numerous biological processes including oxidative stress and inflammation. These stressors can lead to a breakdown of natural cellular processes, impacting the integrity of skin tissue. As a result of oxidative stress, skin cells lose their ability to produce and consume energy (also known as cellular bioenergetics), which leads to reduced levels of cellular energy molecules (ATP and NAD+). P&G scientists have determined that by reducing the negative effects of oxidative stress, skin may be protected from microdamage events that can lead to visible photoaging of skin.

For the first time, in the current study, P&G Beauty & Grooming scientists discovered niacinamide's (vitamin B3) ability to help prevent and reverse damage to cellular metabolism, which is the total of all the biochemical reactions taking place within a skin cell. Through the application of advanced cellular bioenergetics technologies, findings demonstrated that in vitro skin cells under oxidative stress conditions experience a significant decrease in ATP, which leads to reduced cellular activity. Older cells, in particular, showed a heightened sensitivity to oxidative stress response, suggesting that aging and environmental factors negatively impact cells' ability to produce and consume energy. Overall, the combination of niacinamide, pal-KTTKS and an olive oil derivative has been shown in vitro to help restore aged skin cells' response to a younger state.

Significant Protection from Event Sweat - Without a Prescription (P6677)

Perspiration due to heat and activity is primarily driven by secretions from the eccrine glands, which are found all over the body. However, perspiration due to stress involves immediate release of sweat from the eccrine glands as well as secretion from the apocrine glands. Unlike eccrine secretions, the apocrine secretion is rich in organic materials such as proteins and lipids, and acts as a substrate for bacterial growth, resulting in malodor or body odor.

In this study, P&G Beauty & Grooming scientists examined a group of women in stressful situations to evaluate the effectiveness of a Clinical Strength OTC (Secret Clinical Strength) antiperspirant/deodorant. Each woman was treated with the product under one arm while the other arm was left untreated as a control measure. After four days of treatment, the women were assessed through the Trier Social Stress Test (TSST), a method that evaluates stress effects by using physiological responses such as heart rate and salivary cortisol before, during and after a stressful event.

Wetness and odor evaluations were then collected from pads placed in the underarm and shipped to expert odor graders for assessment. The underarms treated with a Clinical Strength OTC showed a wetness reduction of more than 85 percent and odor reduction more than 50 percent during significant psychosocial stress.

Improvement in Facial Skin Appearance by a Cosmetic Treatment Regimen: A Case Study in Identical Twins (P6680)

By comparing facial photodamage in a pair of identical twins, P&G assessed the results of a long-term treatment regimen with a commercially available cosmetic product (Olay Professional Pro-X Intensive Wrinkle Protocol). The twin showing more facial skin photodamage at baseline (Twin "B") was placed on a daily regimen of cosmetic products designed to treat the signs of photoaging. The twin showing less facial photodamage (Twin "A") did not change from her current skin care treatment program, serving as the control. The cosmetic regimen included a deep wrinkle treatment, a daily moisturizer with SPF 30 sunscreen and a nighttime cream, which contained combinations of niacinamide, anti-aging peptides, antioxidants and retinyl propionate. The regimen also included daily use of a powered facial cleansing brush in combination with an exfoliating cleanser (Olay Professional Pro-X Advanced Cleansing System). P&G Beauty & Grooming scientists tracked the results of the regimen on each of the twins' facial skin every three months for a total of 10 months.

At the end of the 10-month treatment period, Twin "B" showed nearly the same level of facial hyperpigmentation and essentially the same skin color lightness compared to her sister. These results demonstrate an improvement in facial skin appearance and a noticeable improvement in the visible signs of photoaging when using the Olay Professional Pro-X treatment regimen long term.

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