OAKLAND, Calif., June 12 --Girls between 9 and 12 years of age with higher-than-average levels of bisphenol-A (BPA) in their urine had double the risk of being obese than girls with lower levels of BPA, according to a Kaiser Permanente study published today in the journal PLOS ONE.
"This study provides evidence from a human population that confirms the findings from animal studies -- that high BPA exposure levels could increase the risk of overweight or obesity," said De-Kun Li, MD, PhD, principal investigator of the study and a reproductive and perinatal epidemiologist at the Kaiser Permanente Division of Research in Oakland, Calif.
BPA is used to make plastics and other materials, such as cash register receipts. It is a known endocrine disruptor with estrogenic properties. In children and adolescents, BPA is likely to enter the body primarily through the ingestion of foods and liquids that have come into contact with BPA-containing materials, Dr. Li said.
"Girls in the midst of puberty may be more sensitive to the impacts of BPA on their energy balance and fat metabolism," Dr. Li said. While BPA is still being examined, he said it has been shown to interfere with a body's process of relating fat content and distribution.
The study -- the first specifically designed to examine the relationship between BPA and obesity in school-age children -- was conducted in Shanghai as part of a larger national study of puberty and adolescent health.
Dr. Li and colleagues studied 1,326 male and female children in grades 4 to 12 at three Shanghai schools (one elementary, one middle and one high school). In addition to urine samples collected with BPA-free materials, they obtained information on other risk factors for childhood obesity, such as dietary patterns, physical activity, mental health and family history.
The researchers found that in girls between 9 and 12 years old, a higher-than-average level of BPA in urine (2 micrograms per liter or greater) was associated with twice the risk of having a body weight in the top 10th percentile for girls of their age in the same population.
The impact was particularly pronounced among 9- to 12-year-old girls with extremely high levels of BPA in their urine (more than 10 micrograms per liter): their risk of being overweight (in the top 10th percentile) was five times greater.
The researchers did not identify significant BPA effects in any other groups studied, including girls over 12 years of age and boys of all ages.
Among all the 9- to 12-year-old girls studied, 36 percent of those with a higher-than-average level of BPA in their urine were overweight or obese compared with 21 percent of those with a lower-than-average level of BPA.
"Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr. Li and co-authors wrote in PLOS ONE. "Worldwide exposure to BPA in the human population may be contributing to the worldwide obesity epidemic."
The PLOS ONE study is the latest in a series published by Dr. Li and his colleagues examining the effects of BPA in humans:
- A 2009 study in Human Reproduction found that exposure to high levels of BPA in the workplace increased the risk of sexual dysfunction in men.
- A 2010 study in the Journal of Andrology found that increasing BPA levels in urine were associated with worsening male sexual function.
- A 2011 study in the journal Fertility and Sterility showed that increasing urine BPA levels were significantly associated with decreased sperm concentration, decreased total sperm count, decreased sperm vitality and decreased sperm motility.
- A 2011 study in the Journal of Reproductive Toxicology showed that parental exposure to BPA during pregnancy was associated with decreased birth weight in offspring.
- A 2011 study in Birth Defects Research (Part A) found that in-utero exposure to BPA was related to anogenital distance (the physical distance between the anus and the genitalia) in male offspring.
- A 2013 study in Fertility and Sterility showed that male workers exposed to BPA in a chemical plant for 6 months or more had lower testosterone levels in their blood than with those who were not exposed to BPA in workplace.
Kaiser Permanente is committed to researching and sourcing safer alternatives to products that may contain potentially harmful chemicals such as BPA. To that end, Kaiser Permanente's Sustainability Scorecard for Medical Products requires suppliers and manufacturers to disclose the presence of BPA in products. Most recently, the organization was able to eliminate BPA from packaging of supplemental nutrition and infant formula products.
In addition to Dr. Li, co-authors of the study were: Maohua Miao, MD, PhD, Xiaoqin Liu, MD, Siqui Wang, PhD, Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research and WHO Collaborating Center for Occupational Health, Shanghai; ZhiJun Zhou, MD, PhD, Chunhua Wu, PhD, School of Public Health, Key Lab for Public Health and Safety and WHO Collaborating Center for Occupational Health, Fudan University, Shanghai; Huijing Shi, PhD, Department of Child and Adolescent Health, Fudan University, Shanghai; and Wei Yuan, MD, PhD, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai.
The study was funded in part by National Natural Science Foundation of China (#81172684).
About the Kaiser Permanente Division of Research
The Kaiser Permanente Division of Research conducts, publishes and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and society at large. It seeks to understand the determinants of illness and well-being, and to improve the quality and cost-effectiveness of health care. Currently, DOR's 550-plus staff is working on more than 250 epidemiological and health services research projects. For more information, visit http://www.
About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve more than 9.1 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. For more information, go to: kp.org/newscenter.