Public Release:  Now hear this: Scientists discover compound to prevent noise-related hearing loss

New research in The FASEB Journal suggests that excessive noise activates certain cells in the ear causing them to detach and damage the blood barrier

Federation of American Societies for Experimental Biology

Bethesda, MD -- Your mother was right when she warned you that loud music could damage your hearing, but now scientists have discovered exactly what gets damaged and how. In a research report published in the September 2013 issue of The FASEB Journal, scientists describe exactly what type of damage noise does to the inner ear, and provide insights into a compound that may prevent noise-related damage.

"Noise-induced hearing loss, with accompanying tinnitus and sound hypersensitivity is a common condition which leads to communication problems and social isolation," said Xiaorui Shi, M.D., Ph.D., study author from the Department of Otolaryngology/Head and Neck Surgery at the Oregon Hearing Research Center at Oregon Health and Science University in Portland, Oregon. "The goal of our study is to understand the molecular mechanisms well enough to mitigate damage from exposure to loud sound."

To make this discovery, Shi and colleagues used three groups of 6 - 8 week old mice, which consisted of a control group, a group exposed to broadband noise at 120 decibels for three hours a day for two days, and a third group given single-dose injections of pigment epithelium-derived factor (PEDF) prior to noise exposure. PEDF is a protein found in vertebrates that is currently being researched for the treatment of diseases like heart disease and cancer. The cells that secrete PEDF in control animals showed a characteristic branched morphology, with the cells arranging in a self-avoidance pattern which provided good coverage of the capillary wall. The morphology of the same cells in the animals exposed to wide-band noise, however, showed clear differences -- noise exposure caused changes in melanocytes located in the inner ear.

"Hearing loss over time robs people of their quality of life," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "It's easy to say that we should avoid loud noises, but in reality, this is not always possible. Front-line soldiers or first responders do not have time to worry about the long-term effects of loud noise when they are giving their all. If, however, a drug could be developed to minimize the negative effects of loud noises, it would benefit one and all."

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Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 27 societies with more than 110,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Fei Zhang, Min Dai, Lingling Neng, Jin Hui Zhang, Zhongwei Zhi, Anders Fridberger, and Xiaorui Shi. Perivascular macrophage-like melanocyte responsiveness to acoustic trauma -- a salient feature of strial barrier associated hearing loss. FASEB J September 2013 27:3730-3740, doi:10.1096/fj.13-232892 ; http://www.fasebj.org/content/27/9/3730.abstract

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