[ Back to EurekAlert! ] Public release date: 6-Aug-2013
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Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles

UCLA prostate cancer research program receives $11.6 million federal grant

National Cancer Institute renews SPORE funding for 5-year cycle

UCLA's Jonsson Comprehensive Cancer Center and the department of urology at the David Geffen School of Medicine at UCLA have been notified that their standing as a National Cancer Institute Specialized Program of Research Excellence (SPORE) site in prostate cancer has been renewed for another five years.

The UCLA program is under the leadership of principal investigator Dr. Robert Reiter, Bing Professor of Urologic Research and a member of the Jonsson Cancer Center.

This renewal marks the beginning of a third five-year cycle of funding that will support UCLA scientists' efforts to improve the prevention, detection and treatment of prostate cancer. Thirty-thousand American men are expected to die from the disease this year, and the NCI estimates that more than 238,000 men will be diagnosed with prostate cancer in 2013.

The SPORE program is a central component of NCI's efforts to spur collaborative, interdisciplinary cancer research at academic centers throughout the U.S., with the goal of translating basic research from the laboratories into patient care more quickly and effectively. The five-year, $11.6 million grant will help UCLA expand its renowned prostate cancer program, which engages researchers and clinicians from many disciplines across campus to uncover the mysteries of the disease.

"The SPORE grant will robustly continue the outstanding programs we have developed over the last two cycles of the grant and give us the resources to bring investigators together for new innovative and multidisciplinary projects with the goal of improving the way we diagnose and treat prostate cancer," said Dr. Mark Litwin, professor and chair of UCLA's department of urology.

"This renewal of the UCLA prostate SPORE is indicative of the world-class research we have on this campus," said Dr. James Economou, UCLA vice chancellor for research and professor of microbiology, immunology and molecular genetics; molecular and medical pharmacology; and surgical oncology.

"The renewal of this SPORE grant is affirmation of the leadership role UCLA continues to play in groundbreaking research on prostate cancer," said Dr. Eugene Washington, vice chancellor for health sciences and dean of the Geffen School of Medicine.

"Over the past 10 years, the UCLA prostate SPORE has had some great successes," Reiter said. "Among them have been the development of the drug enzalutamide by Dr. Charles Sawyers and Dr. Michael Jung, the identification of prostate stem cells by Dr. Owen Witte and colleagues, and the discovery and development of antibodies against the prostate stem-cell antigen gene, which have all gone from discovery through to clinical trials. Other highlights include Dr. Hong Wu's work on the PTEN tumor suppressor gene, demonstrating that the gene negatively regulates prostate cancer stem cell self-renewal, proliferation and survival, and the work of Dr. Bill Aronson and colleagues demonstrating that dietary changes can affect the growth rate of prostate tumors."

According to the NCI, SPORE grants are designed to promote collaboration among the best scientific minds. The grants bring together researchers who might not otherwise have a chance to work together. The UCLA prostate SPORE is the only one in California and one of a handful in the U.S.

The specific aims of the renewed grant are:

The SPORE grant will primarily fund four projects at UCLA:

Jonsson Cancer Center director Dr. Judith Gasson, a professor of medicine and senior associate dean for research, said that UCLA's prostate cancer program is a shining example of the campus's excellence in interdisciplinary research.

"We'll be able to move forward more quickly now to develop new and better ways to prevent, diagnose and treat prostate cancer with the goal of saving tens of thousands of lives every year," she said.

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UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2013, the Jonsson Cancer Center was named among the top 12 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 14 consecutive years.

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