Should surgery be performed immediately, or is it better to first administer antibiotics and then perform surgery? A study led by Heidelberg University Hospital Department of Surgery has demonstrated that patients suffering from acute cholecystitis should be operated on immediately. There are no advantages to delaying surgery until antibiotic therapy has been administered for several weeks. After undergoing surgery performed within 24 hours of diagnosis, the patients have fewer complications, are back on their feet earlier, and can leave the hospital more quickly. "With this study, we were finally able to present scientific evidence that allows us to resolve years of controversy," explained Prof. Markus W. Büchler, Director of Heidelberg University Hospital's Department of Surgery. The results of the ACDC study ("Acute cholecystitis – early laparoscopic surgery versus antibiotic therapy and delayed elective cholecystectomy") have now been published in the U.S. journal Annals of Surgery.
The major risk factors for acute inflammation of the gallbladder (cholecystitis) are gallstones and increasing age. If left untreated, the gallbladder can rupture, leading to severe infections in the adjacent organs and in the abdominal cavity. Today, the gallbladder is usually removed laparoscopically without requiring a large abdominal incision. However, previously there was no consensus on the optimal timing for the procedure.
Fewer complications and complaints when surgery is performed immediately after admission
The ACDC study was jointly conducted by surgeons and internists at several centers in Germany. It is the first clinical study to prospectively investigate the two treatment approaches – early and delayed surgery – and involved two large groups composed of approximately 300 patients each who were randomly assigned to the groups.
The treatment outcomes were analyzed 75 days post-surgery. Patients undergoing early surgery reported significantly fewer complaints and complications (11.8%) compared to patients in whom an initially conservative approach (34.4%) was used. In economic terms, too, the evidence points to the advantages of early gallbladder removal: Patients undergoing surgery immediately stayed in the hospital only 5.4 days on average compared to patients for whom surgery was delayed, whose stays were 10 days on average. This translated into significantly lower hospitalization costs (€2,919/€4,262).The ACDC study's authors concluded that "immediate laparoscopic cholecystectomy should become the therapy of choice for acute cholecystitis in operable patients."
World-class General, Visceral and Transplantation Surgery Department
The Heidelberg General, Visceral and Transplantation Surgery has an outstanding reputation worldwide – thanks to its excellence in abdominal surgery and transplantation. Every year, around 5.000 patients are treated on an inpatient basis, with around 50.000 undergoing outpatient treatment. The interdisciplinary team performs over 8.000 visceral surgical procedures annually, 1.100 of which involve the gallbladder.
Prof. Markus W. Büchler, Managing Director of Heidelberg University Hospital's Department of Surgery Photo: Heidelberg University Hospital.
Literature: Gutt, C., Buechler MW et al: Acute Cholecystitis – Early Versus Delayed Cholecyytectomy, A Multicenter Randomised Trial, Annals of Surgery 2013; 258 (3): 385-393 / doi: 10.1097/SLA.0b013e3182a1599b)
For more information, go to the website at:
Five questions for Prof. Markus Büchler on the ACDC study in the "Ärzteblatt online" (in German): http://www.aerzteblatt.de/nachrichten/55679/Akute-Cholezystitis-Fruehzeitige-Operation-ist-dem-konservativen-Vorgehen-ueberlegen
Heidelberg University Hospital's Department of Surgery homepage: http://www.klinikum.uni-heidelberg.de/index.php?id=100293&L=1
Prof. Markus W. Büchler
Heidelberg University Hospital – Department of Surgery
Email to department office: Irmgard.Alffermann@med.uni-heidelberg.de
Tel: +49 (0)6221 56-6201
Heidelberg University Hospital and Medical Faculty: Internationally recognized patient care, research, and teaching
Heidelberg University Hospital is one of the largest and most prestigious medical centers in Germany. The Medical Faculty of Heidelberg University belongs to the internationally most renowned biomedical research institutions in Europe. Both institutions have the common goal of developing new therapies and implementing them rapidly for patients. With about 11,000 employees, training and qualification is an important issue. Every year, around 118,000 patients are treated on an inpatient basis and around 1.000.000 cases on an outpatient basis in more than 50 clinics and departments with 2,200 beds. Currently, about 3,500 future physicians are studying in Heidelberg; the reform Heidelberg Curriculum Medicinale (HeiCuMed) is one of the top medical training programs in Germany.
Requests by journalists:
Dr. Annette Tuffs
Director, Corporate Communication/Public Relations
University Hospital and Medical Faculty of Heidelberg
Im Neuenheimer Feld 672
phone: +49 6221 / 56 45 36
fax: +49 6221 / 56 45 44
Selected english press releases online: http://www.klinikum.uni-heidelberg.de/presse
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.