BOSTON (Sept. 17, 2013) — Researchers from the Eaton-Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells -- the sensory cells that detect sound and sense balance -- protects the mice from age-related hearing loss (ARHL) and noise-induced hearing loss (NIHL), the two most common forms of deafness.
Their research, described in the Journal Neuroscience, provides new insight into protective mechanisms for hearing loss and suggests the potential for future molecular approaches, which may include gene therapy or medicine, to treat ARHL and NIHL.
Hearing loss is a serious public health issue. Nearly one-third of adults 64 and older have significant ARHL. After age 85, that number almost doubles to 64 percent. NIHL, also a common complaint, is one of the most self-reported occupational injuries. The irreversible loss of inner ear outer cells is a cause of both types of hearing loss. Hearing aids and cochlear implants help those suffering from hearing loss in some cases, but there is no device that works for everyone and no cure.
Mass. Eye and Ear researchers set out to understand if both types of hearing loss share a common underlying mechanism by studying certain inbred strain of mice. They investigated whether overexpression of Isl1, an inner ear progenitor gene with roles in development and differentiation, could be effective in protecting the inner ear.
The team found that Isl1 expression protected hair cells from degeneration in aging and promoted hair cell survival after exposure to loud noise. As a result, the hearing in aged mice or in mice exposed to intense noise was significantly better than their siblings without the gene.
"The Isl1 gene further preserved the connections between hair cells and neurons, which is necessary for hearing," said senior author Zheng-Yi Chen, D.Phil., Mass. Eye and Ear researcher and Associate Professor of Otolaryngology, Harvard Medical School.
Future research can evaluate if Isl1 is protective from ARHL and NIHL in other mouse strains. The investigators hope to eventually study if such protection can be extended to the human condition.
"To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age-related and noise-induced hearing loss," Dr. Chen said.
This work was funded by grants R01 DC0690, R01 DC 00188 and P30 DC 05029 from the National Institute on Deafness and other Communication Disorders (NIDCD), by the Fredrick and Ines Yeatts Inner Ear Hair Cell Regeneration Fellowship, the Bertarelli Foundation, the Ellison Foundation and by the Capita Foundation.
A full list of authors is available in the paper.
About Massachusetts Eye and Ear
Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. The Eaton-Peabody Laboratories (EPL), founded in 1958, comprise a multi-disciplinary group of 27 Investigators within 11 Research Units dedicated to the study of hearing and deafness. EPL Investigators include clinicians and basic scientists, who bring together scientific strengths in neuroanatomy, physiology, psychology, pharmacology, electrical engineering, physics, mathematics, molecular biology, immunology, cell biology and genetics.
Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation.
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