Autografts or allografts are commonly used in the repair of damaged peripheral nerves. However, similar problems have been encountered in allografting or xenografting. Previous studies concerning artificial neural tubes to repair nerve defects mainly focus on peripheral nerve defects less than 30 mm. Dr. Esmaeil Biazar and colleagues from Islamic Azad University, Iran investigate the feasibility of poly(3-hydroxy- butyrate-co-3-hydroxyvalerate) conduits in the repair of 30-mm sciatic nerve gap in a rat model. The researchers found that at 4 months after nerve conduit implantation, regenerated nerves were macroscopically observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber. There were Schwann cells and glial cells in the regenerated nerves. Masson's trichrome staining showed that there were no pathological changes in the size and structure of gastrocnemius muscle cells on the operated side of rats. These findings, published in the Neural Regeneration Research (Vol. 8, No. 24, 2013), suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit is suitable for repair of long-segment sciatic nerve defects. Results from Dr. Esmaeil Biazar and colleagues offer a novel solution for repair of long-segment peripheral nerve defects in the clinic.
Article: " Nanofibrous nerve conduits for repair of 30-mm-long sciatic nerve defects," by Esmaeil Biazar1, Saeed Heidari Keshel2, 3, Majid Pouya4, Hadi Rad4 , Melody Omrani Nava4, Mohammad Azarbakhsh5, Shirin Hooshmand5 (1 Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran; 2 Student Research Committee, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3 Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4 Department of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran; 5 Faculty of Medical Sciences, Babol University of Medical Sciences, Babol, Iran)
Biazar E, Heidari SK, Pouya M, Rad H, Nava MO, Azarbakhsh M, Hooshmand S. Nanofibrous nerve conduits for repair of 30-mm-long sciatic nerve defects. Neural Regen Res. 2013;8(24):2266-2274.
Contact: Meng Zhao firstname.lastname@example.org 86-138-049-98773 Neural Regeneration Research http://www.nrronline.org/
Full text: http://www.sjzsyj.org:8080/Jweb_sjzs/CN/article/downloadArticleFile.do?attachType=PDF&id=699
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.