Irritable bowel syndrome patients extensively suffer from chronic visceral hypersensitivity, with involvement of all levels of the brain-gut axis, as well as various neurotransmitters. Chronic visceral hypersensitivity can occur in the periphery, spinal cord and central nervous system, which has been shown to be the main pathophysiological mechanism underlying abdominal pain in patients with irritable bowel syndrome. Acupuncture at Tianshu (ST25) and Shangjuxu (ST37) has been reported to relieve visceral hypersensitivity for irritable bowel syndrome. Xinxin Guo and colleagues from the Third Affiliated Hospital of Zhejiang Chinese Medical University found that electroacupuncture treatment can improve visceral hypersensitivity in irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord. This finding, published in the Neural Regeneration Research (Vol. 8, No. 22, 2013), provides medical support to reveal the central mechanisms underlying electroacupuncture treatment for irritable bowel syndrome.
Article: " Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity," by Xinxin Guo1, Jifei Chen2, Yuan Lu3, Luyi Wu3, Zhijun Weng3, Ling Yang3, Yuhu Xin4, Xianming Lin1, Yi Liang1, Jianqiao Fang1 (1 Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China; 2 Department of Orthopedics, Zhongshan Hospital of Fudan University, Shanghai 200032, China; 3 Shanghai Institute for Traditional Chinese Medicine, Shanghai 201203, China; 4 Cancer Hospital, Fudan University, Shanghai 200032, China)
Guo XX, Chen JF, Lu Y, Wu LY, Weng ZJ, Yang L, Xin YH, Lin XM, Liang Y, Fang JQ. Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity. Neural Regen Res. 2013;8(22):2069-2077.
Contact: Meng Zhao
Neural Regeneration Research
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