Previous studies by Shaohua Gu and team from Shanghai Pudong New Area Zhoupu Hospital showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was increased after the autophagy inhibitor, 3-methyladenine, was used, indicating autophagy may be involved in mediating neuronal death in cerebral ischemia. A recent study reported by Gu et al showed that autophagic and lysosomal activity is increased in ischemic neurons, and the activation of autophagic and lysosomal pathways can provide nutrition and energy for the survival of ischemic neurons, which was published in the Neural Regeneration Research (Vol. 8, No. 23, 2013). Researchers believe that abnormal components in cells can be eliminated through upregulating cell autophagy or inhibiting autophagy after ischemic brain injury, resulting in a dynamic balance of substances in cells. Moreover, drugs that interfere with autophagy may be potential therapies for the treatment of brain injury.
Article: " The role of autophagic and lysosomal pathways in ischemic brain injury," by Zhaohua Gu1, Yinyi Sun2, Kangyong Liu1, 2, Fen Wang3, Ting Zhang2, Qiang Li2, Liwei Shen4, Ling Zhou4, Liang Dong1, Nan Shi1, Qian Zhang1, Wei Zhang1, Meizhen Zhao1, Xiaojiang Sun2 (1 Department of Neurology, Shanghai Pudong New Area Zhoupu Hospital, Shanghai 234318, China; 2 Department of Neurology, the Sixth People's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200233, China; 3 Department of Neurobiology, Suzhou University School of Medicine, Suzhou 215123, Jiangsu Province, China; 4 Department of Neurology, the Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China)
Gu ZH, Sun YY, Liu KY, Wang F, Zhang T, Li Q, Shen LW, Zhou L, Dong L, Shi N, Zhang Q, Zhang W, Zhao MZ, Sun XJ. The role of autophagic and lysosomal pathways in ischemic brain injury. Neural Regen Res. 2013;8(23):2117-2125.
Contact: Meng Zhao
Neural Regeneration Research
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