A new $4.47 million project at the University of North Carolina at Chapel Hill, funded by the Defense Threat Reduction Agency, will help lay the groundwork for developing potentially better ways to deliver antidotes against exposure to chemical weapons. The work could ultimately help both civilian and military populations through the design of precisely engineered particles and microneedle patches that are loaded with a nerve gas antidote that can be easily administered in the event of an attack.
Researchers at UNC will use the PRINT® technology, also known as Particle Replication In Non-wetting Templates, to design and optimize the size, shape and composition of particles and microscopic needles that can carry life-saving antidotes to chemical nerve gas. If successful, the application of this technology could make it easier to deliver drugs faster to counteract severe reactions to chemical agents.
"Finding the fastest, most effortless method to administer antidotes during a nerve gas attack can be crucial for saving lives," said Joseph DeSimone, Chancellor's Eminent Professor of Chemistry at UNC and William R. Kenan Jr. Distinguished Professor of Chemical Engineering at N.C. State University and of Chemistry at UNC.
A central part of the five-year project will be to optimize the design attributes of precisely uniform arrays of microneedles, tiny structures that would be incorporated into a patch that can be applied directly to the skin where the microneedles dissolve for rapid absorption of the nerve gas antidote. Once the mode of delivery is optimized, the PRINT technology also allows for large-scale manufacturing of these microneedle patches and other possible antidote systems.
"Every second matters when someone is exposed to a chemical agent, so identifying a way to simply slap a patch onto someone's arm, in an instant, could have a life-saving impact," said DeSimone. "We are trying to find the best way to make the delivery of an antidote easy, effective and widely accessible."
DeSimone, who will lead the project, invented the PRINT technology with his students in 2004. The PRINT technology is licensed to Liquidia Technologies (Research Triangle Park, NC) for the development of a wide range of vaccines and therapeutics. Liquidia was co-founded by DeSimone, also in 2004.
Note from granting agency: The project or effort depicted was or is sponsored by the Department of the Defense, Defense Threat Reduction Agency. The content of the information does not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred. One hundred percent of the total costs of this project, $4.47 million, will be financed with federal money under the new grant.