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PUBLIC RELEASE DATE:
25-Oct-2013

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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research

Salvianolate for treatment of cerebral ischemia-reperfusion injuries

IMAGE: Brown cells are terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells undergoing apoptosis (× 400).

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Salvianolic acid B, also called salvia magnesium acetate, is a phenolic acid compound composed of three Danshensu units and one molecule of caffeic acid. Salvianolic acid B exerts strong resistance to oxidative stress and inflammatory reaction, and improves energy metabolism against cerebral ischemia-reperfusion injuries. Dr. Wei Lu and his team from the Second Xiangya Hospital, Central South University, China found that administration of salvianolate during reperfusion after ischemia appears to attenuate brain tissue damage and inhibit neuronal apoptosis by increasing heat shock protein 22 and phosphorylated protein kinase B expression. These findings were published in the Neural Regeneration Research (Vol. 8, No. 25, 2013).

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Article: "Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model" by Jinnan Zhang, Wei Lu, Qiang Lei, Xi Tao, Hong You, Pinghui Xie (Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China)

Zhang JN, Lu W, Lei Q, Tao X, You H, Xie PH. Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model. Neural Regen Res. 2013;8(25):2327-2335.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=705



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