Caveolin-1 may be a new target for interfering with age-dependent decline in synaptic plasticity. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, Dr. Yang Liu and coworkers from the First Affiliated Hospital, Dalian Medical University, China examined synaptophysin expression in the hippocampus, cortex and cerebellum of rats at different ages, and analyzed the association between synaptophysin expression and cognition and behaviors. Results showed that caveolin-1 and synaptophysin declined with age in the hippocampus, and synaptophysin levels were strongly associated with age-related memory impairment. The researchers have provided the first direct demonstration that caveolin-1 protein expression changes in an age-dependent manner. Synaptophysin revealed a similar expression pattern to that of caveolin-1 in the hippocampus, cortex and cerebellum. This new notion might be helpful in strategic decision-making and preventing aging-induced loss of synaptic plasticity. The relevant study was published in the Neural Regeneration Research (Vol. 8, No. 29, 2013).
Article: " Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats," by Yang Liu1, Zhanhua Liang2, Jing Liu1, Wei Zou3, Xiaoyan Li1, Yachen Wang2, Lijia An4 (1 Regenerative Medicine Center, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China; 2 Department of Neurology, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China; 3 Department of Biology, Liaoning Normal University, Dalian 116023, Liaoning Province, China; 4 School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning Province, China)
Liu Y, Liang ZH, Liu J, Zou W, Li XY, Wang YC, An LJ. Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats. Neural Regen Res. 2013;8(29):2725-2733.