Hypoxic preconditioning has been shown to have protective effects against acute cerebral infarction. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, Prof. Xunming Ji and team from Xuanwu Hospital, Capital Medical University in China induced a photochemical model of cerebral infarction in an inbred line of mice (BALB/c) which were exposed to hypoxic preconditioning prior to model establishment. The researchers found that hypoxic preconditioning reduced infarct volume and attenuated the impairment of neurological function. These neuroprotective effects were related to increased vascular endothelial growth factor and CD31 expression, which promoted angiogenesis. These findings were published in the Neural Regeneration Research (Vol. 8, No. 31, 2013).
Article: "Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction " by Sijie Li1, Yanbo Zhang2, Guo Shao3, Mingfeng Yang2, Jingzhong Niu2, Guowei Lv1, Xunming Ji1 (1 Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China; 2 Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 27100, Shandong Province, China; 3 Research Center of Biology and Medicine, Baotou Medical College, Baotou 014060, Inner Mongolia Autonomous Region, China)
Li SJ, Zhang YB, Shao G, Yang MF, Niu JZ, Lv GW, Ji XM. Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction. Neural Regen Res. 2013;8(31):2895-2903.