[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:
27-Dec-2013

[ | E-mail ] Share Share

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research

Normobaric oxygen preconditioning for cerebral ischemic injury

IMAGE: This is immunohistochemistry showing normobaric oxygen pretreatment increased the expression of Notch-1 in the cerebral cortex of rats with focal cerebral ischemia.

Click here for more information.

Normobaric oxygen has the rapid and non-invasive characteristics and may have therapeutic effects on ischemic/hypoxic disease. Dr. Chunhua Chen and colleagues from Peking University, China found that in rats which inhaled normobaric oxygen before focal cerebral ischemia, neurological deficits were improved and infarct volume was reduced; the expression of hypoxia-inducible factor-1α, Notch-1, vascular endothelial growth factor and erythropoietin were increased; neurological deficit scores increased; the hypoxia-inducible factor inhibitor 2-methoxyestradiol treatment could suppress the protective effect of normobaric oxygen. Given these observations, normobaric oxygen exposure could prevent cerebral ischemic/reperfusion injury, and this protective effect might be exerted via regulating the hypoxia-inducible factor signaling pathway. This finding, published in the Neural Regeneration Research (Vol. 8, No. 31, 2013), illustrates the beneficial effects of normobaric oxygen application as a potential treatment strategy.

###

Article: " Normobaric oxygen for cerebral ischemic injury," by Chunhua Chen, Haimeng Cui, Zihe Li, Ruifeng Wang, Changman Zhou (Department of Anatomy and Histoembryology, Peking University Health Science Center, Beijing 100191, China)

Chen CH, Cui HM, Li ZH, Wang RF, Zhou CM. Normobaric oxygen for cerebral ischemic injury. Neural Regen Res. 2013;8(31):2885-2894.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

Full text: http://www.sjzsyj.org/CN/article/downloadArticleFile.do?attachType=PDF&id=762



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.