image: After 3 days of culture, differentiated neural stem cells within the proliferative neurosphere were strongly positive for nestin. The arrow indicates a nestin-positive neurosphere. view more
Credit: <i>Neural Regeneration Research</i>
The electrophysiological properties of potassium ion channels are regarded as a basic index for determining the functional differentiation of neural stem cells. A recent study published in the Neural Regeneration Research (Vol. 8, No. 28, 2013) showed that the proliferating neural stem cells selected were capable of differentiating into neural cells, and the differentiation process was accompanied by the expression of potassium currents. After 2 weeks of differentiation and development, the potassium current density increased sharply. The experimental findings indicate that neural stem cells from newborn rat hippocampus could be cultured and induced to differentiate into functional neurons under defined conditions in vitro. The differentiated neurons expressed two types of outward potassium ion currents similar to those of mature neurons in vivo.
Article: " Two outward potassium current types are expressed during the neural differentiation of neural stem cells," by Ruiying Bai1, Guowei Gao2, Ying Xing1, 3, Hong Xue4 (1 Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China; 2 Department of Radiotherapy, Center Hospital of Xinxiang, Xinxiang 453003, Henan Province, China; 3 Stem Cell Research Center, Zhengzhou University, Zhengzhou 450052, Henan Province, China; 4 Basic Medical Sciences of Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China)
Bai RY, Gao GW, Xing Y, Xue H. Two outward potassium current types are expressed during the neural differentiation of neural stem cells. Neural Regen Res. 2013;8(28):2656-2665.
Contact: Meng Zhao
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Journal
Neural Regeneration Research