Bethesda, MD - This 2014 FASEB Science Research Conference focuses on recent advances in our understanding of the mechanism of action of G protein-coupled receptor kinases (GRKs), their physiological functions, and their role in pathological conditions. GRKs are key regulatory proteins that, together with arrestins, determine the rate and extent of homologous desensitization of G protein-coupled receptors (GPCR). GPCRs mediate responses to hormones and neurotransmitters in multiple tissues and cell types and are targeted by half of clinically used drugs.
Therefore, proteins that regulate the GPCR signaling are likely to be critical for a variety of diseases and represent important therapeutic targets. Recent seminal discoveries attracted attention to novel aspects of GRK biology, such as GRK-dependent regulation of non-GPCR receptors and control of GPCR signaling by GRKs in a phosphorylation-independent manner.
This FASEB meeting will bring together researchers studying varying aspects of GRK biology in the rapidly expanding field of GRK research, from structural biologists to physiologists and physician-scientists. The discussions will broaden our understanding of fundamental aspects of function of these exciting proteins and facilitate novel collaborations. The interdisciplinary nature of this meeting stems from appreciation that only joint effort of investigators studying the mechanisms of GRK action in different model system from pure proteins to living animals will overcome challenges that remain in the GRK field and will allow to fully exploit the potential of GRKs as therapeutic targets.
FASEB has announced a total of 35 Science Research Conferences (SRC) in 2014. Registration opens January 17, 2014. For more information about an SRC, view preliminary programs, or find a listing of all our 2014 SRCs, please visit http://www.
Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.