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PUBLIC RELEASE DATE:
8-Jan-2014

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Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School

UMass Medical School faculty recognized as 1 of nation's top young scientists

Associate professor Thomas G. Fazzio, Ph.D., receives Presidential Early Career Award for Scientists and Engineers

WORCESTER, MA University of Massachusetts Medical School (UMMS) Assistant Professor Thomas G. Fazzio, PhD, was recognized as a rising scientific star by President Obama with a Presidential Early Career Award for Scientists and Engineers.

The Presidential Award is the highest honor bestowed by the U.S. government on outstanding scientists and engineers in the early phases of their research careers. The award embodies the high priority the Obama Administration places on producing the next generation of scientists and engineers to advance the nation's goals, tackle grand challenges, and contribute to the American economy. Dr. Fazzio was one of 102 scientists and engineers selected for this year's award.

"It's an honor to be chosen, among so many outstanding scientists, for this award by President Obama," said Dr. Fazzio of the Program in Gene Function and Expression at UMMS. "It means a lot to have our work recognized at the national level and to know the value that the President and his administration has for biomedical research and advancing scientific inquiry."

Presidential awardees are selected for their pursuit of innovative research at the frontiers of science and technology and their commitment to community service as demonstrated through scientific leadership, public education, or community outreach. Granted to a select group each year, the awards are intended to showcase and nurture some of the finest scientists and engineers who, while early in their research careers, show exceptional potential for leadership at the frontiers of scientific knowledge.

"Dr. Fazzio is a truly outstanding young investigator. He brings a fresh new perspective to the field, studying the regulation of genes in stem cells from an exciting new angle," said Terence R. Flotte, MD, the Celia and Isaac Haidak Professor of Medical Education, executive deputy chancellor, provost, dean of the School of Medicine and professor of pediatrics. "We are fortunate and very proud to have him as a member of the UMMS scientific community."

A member of the UMass Medical School faculty since 2010, Fazzio's research focuses on understanding how DNA is packaged into tiny chromatin structures inside the nucleus of stem cells. Through his work, Fazzio has uncovered previously unknown processes governing how the chromatin structure of a cell's DNA influences gene expression in stem cells, conferring on these cells the unique ability to replicate and differentiate into many different types of cells.

"We're interested in understanding the biological processes that allow a stem cell to become a muscle cell, a blood cell, or any other kind of cell," said Fazzio. "The knowledge we gain from answering these questions can be used to identify potential new targets for drugs that attack cancer stem cells within tumors and pave the way for the development of stem cell-based therapies for degenerative diseases."

A 2011 Pew Scholar recipient, Fazzio came to UMMS following a post-doctoral fellowship at the University of California San Francisco where he studied chromatin regulation in stem cells in the labs of Barbara Panning, PhD, and J. Michael Bishop, MD. While at UCSF, his work was supported by a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research and a Pathway to Independence Award from the National Institutes of Health.

Fazzio received his PhD from the University of Washington and Fred Hutchinson Cancer Research Center in 2004 for work on yeast chromatin regulation in the lab of Toshio Tsukiyama, PhD, DVM, and completed his undergraduate degree at the University of Utah in 1997 where he studied the genetics of Vitamin B12 metabolism in Salmonella typhimurium in the laboratory of John R. Roth, PhD.

With the funding support associated with the Presidential Award, Fazzio will explore the link between chromatin structures and gene expression in stem cells.

Instituted in 1996, the Presidential Awards embody the high priority placed by the government on maintaining the United States' leadership position in science by producing outstanding scientists and engineers who will broadly advance science and the missions important to the participating agencies, which include the National Science Foundation, National Science and Technology Council, National Aeronautics and Space Administration, Environmental Protection Agency, Department of Agriculture, Department of Commerce, Department of Defense, Department of Energy, Department of Health and Human Services, Department of Transportation and the Department of Veterans Affairs.

Fazzio is the fourth UMass Medical School Presidential Award recipient. In 2011, Associate Professor of Family Medicine and Community Health Chyke Doubeni, MD, MPH, was recognized for his work on identifying and reducing disparities in healthcare. In 2005, Assistant Professor of Medicine Neal S. Silverman, PhD, was recognized with the award for his research into the mechanisms controlling innate immunity. In 2006, Associate Professor of Medicine and Cancer Biology JeanMarie Houghton, MD, PhD, won the award for her work examining the role of stem cells in cancer.

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For more information about the PECASE Award, visit http://grants.nih.gov/grants/policy/pecase.htm

About the University of Massachusetts Medical School

The University of Massachusetts Medical School (UMMS), one of five campuses of the University system, is comprised of the School of Medicine, the Graduate School of Biomedical Sciences, the Graduate School of Nursing, a thriving research enterprise and an innovative public service initiative, Commonwealth Medicine. Its mission is to advance the health of the people of the Commonwealth through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. In doing so, it has built a reputation as a world-class research institution and as a leader in primary care education. The Medical School attracts more than $240 million annually in research funding, placing it among the top 50 medical schools in the nation. In 2006, UMMS's Craig C. Mello, PhD, Howard Hughes Medical Institute Investigator and the Blais University Chair in Molecular Medicine, was awarded the Nobel Prize in Physiology or Medicine, along with colleague Andrew Z. Fire, PhD, of Stanford University, for their discoveries related to RNA interference (RNAi). The 2013 opening of the Albert Sherman Center ushered in a new era of biomedical research and education on campus. Designed to maximize collaboration across fields, the Sherman Center is home to scientists pursuing novel research in emerging scientific fields with the goal of translating new discoveries into innovative therapies for human diseases.



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