Public Release:  JCI early table of contents for Feb. 10, 2014

Journal of Clinical Investigation

Researchers identify unique regulatory T cell population in human skin

Regulatory T cells (Tregs) dampen the immune response against self antigens and contribute to the prevention of autoimmunity. A skin-specific population of Tregs (mTreg) has been described in mice that has properties similar to memory T cells. In mice, some mTregs are maintained in the skin for long periods of time and suppress cutaneous autoimmunity. In this issue of the Journal of Clinical Investigation, Michael Rosenblum and colleagues at the University of California San Francisco analyzed the mTreg population in human skin, and found that human mTregs have unique features and localize to hair follicles. mTregs isolated from human skin did not appear to recognize the same antigens as memory T cells isolated from blood. In healthy skin, mTregs were relatively static; however, this population was greatly expanded in skin from psoriasis patients, suggesting that these cells are dysfunctional in inflamed skin.

TITLE: Memory regulatory T cells reside in human skin

AUTHOR CONTACT: Michael D. Rosenblum
UCSF, San Francisco, CA, USA
Phone: +14153537800; E-mail: rosenblummd@derm.ucsf.edu

View this article at: http://www.jci.org/articles/view/72932?key=dfa6e0f9c00d116b3ce5


Familial amyotrophic lateral sclerosis-associated mutation damages DNA and alters RNA splicing

Familial amyotrophic lateral sclerosis (FALS) is a neurological disease that has been linked to mutations in several different genes, including the gene encoding the DNA/RNA binding protein FUS. It is unclear how FUS mutations promote FALS-associated symptoms. In the issue of the Journal of Clinical Investigation, Eric Huang and colleagues of the University of California San Francisco developed a transgenic mouse model of FUS-associated FALS. FUS-R521C mice exhibited phenotypes similar to patients, such as neurological dysfunction and pronounced DNA damage. The authors identified brain-derived neurotrophic factor (Bdnf) as a target of mutant FUS. Treatment of FUS-R521C neurons with BNDF only partially restored dendrite function. Evaluation of spinal cords from FUS-R521C revealed that there were multiple defects in the transcription and splicing of genes associated with dendrite growth and function.

TITLE: ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

AUTHOR CONTACT: Eric Huang
University of California San Francisco UCSF, San Francisco, CA, USA
Phone: 415-476-8525; Fax: 415-514-0878; E-mail: eric.huang2@ucsf.edu

View this article at: http://www.jci.org/articles/view/72723?key=bee22d69afd746aef369


ALSO IN THIS ISSUE

TITLE: Optogenetic stimulation of the auditory pathway

AUTHOR CONTACT: Tobias Moser
University Medical Center Göttingen, Göttingen, , DEU
Phone: 551-39-8968; E-mail: tmoser@gwdg.de

View this article at: http://www.jci.org/articles/view/69050?key=74465b973953e5ba1dd3

TITLE: B cells mediate chronic allograft rejection independently of antibody production

AUTHOR CONTACT: Geetha Chalasani
University of Pittsburgh, Pittsburgh, PA, USA
Phone: (412) 383-5924; Fax: (412) 383-9990; E-mail: gec12@pitt.edu

View this article at: http://www.jci.org/articles/view/70084?key=e22afdb8ee7de68e72ed

TITLE: 5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy

AUTHOR CONTACT: Christine Edry Seidman
Brigham & Women's Hospital/Harvard Medical School, Boston, MA, USA
Phone: 617-432-7838; Fax: 617-432-7832; E-mail: cseidman@genetics.med.harvard.edu

View this article at: http://www.jci.org/articles/view/70108?key=f64e28fb026d750a312d

TITLE: CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis

AUTHOR CONTACT: Stefan Kaufmann
Max Planck Institute for Infection Biology, Berlin, , DEU
E-mail: kaufmann@mpiib-berlin.mpg.de

View this article at: http://www.jci.org/articles/view/72030?key=1d74463dd0b5db358c19

TITLE: IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking

AUTHOR CONTACT: John Harty
University of Iowa, Iowa City, IA, USA
Phone: 319-335-9720; Fax: 319-335-9006; E-mail:john-harty@uiowa.edu

View this article at: http://www.jci.org/articles/view/72039?key=d0407b540a1c644da93b

TITLE: An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

AUTHOR CONTACT: Ira A. Tabas
Rm PH 8-East 105F, New York, NY, USA
Phone: 212-305-9430; Fax: 212-305-4834; E-mail: iat1@columbia.edu

View this article at: http://www.jci.org/articles/view/72051?key=b5676b497b6cff5d0770

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