Public Release:  JCI early table of contents for Feb. 17, 2014

Journal of Clinical Investigation

Neurotensin conjugate provides pain relief in animal models

The small peptide neurotensin is a potent regulator of dopamine signaling and can provide dramatic pain relief; however, the blood brain barrier provides a substantial challenge toward clinical use of neurotensin for analgesia. In this issue of the Journal of Clinical Investigation, Philippe Sarret and colleagues at Université de Sherbrooke generated a conjugate of neurotensin with a peptide able to cross the blood brain barrier and evaluated the analgesic effects of this molecule in animal models of pain. The authors observed efficient transportation of the conjugate (ANG2002) across the blood brain barrier and dose-dependent pain relief in multiple models. The results from this study suggest that ANG2002 has potential to be effective for clinical pain management.

TITLE: Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties

AUTHOR CONTACT: Philippe Sarret
Université de Sherbrooke, Sherbrooke, PQ, CAN
Phone: 819-820-6868 #12554; Fax: 819-820-6887; E-mail:

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T cell repertoire following hematopoietic stem cell transplant

A promising treatment for hematologic and other malignancies is the transplantation of hematopoietic stem cells isolated from the patient. The use of an individuals own stem cells reduces complications involved with graft rejection;however, many patients develop autoimmune disease or other complications following the procedure. In this issue of the Journal of Clinical Investigation, Laurence Turka and colleagues from Massachusetts General Hospital evaluated the T cell response in a cohort of poor-prognosis MS patients following hematopoietic stem cell transplantation (HSCT) and determined that HSCT had differential effects on T cell repertoire. Importantly, patients with a diverse T cell population following the procedure were more likely to respond well to treatment.

TITLE: T cell repertoire renewal following autologous stem cell transplantation for multiple sclerosis

AUTHOR CONTACT: Laurence A. Turka
Massachusetts General Hospital, Boston, MA, USA
Phone: 617 724-7711; Fax: ; E-mail:

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TITLE: Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson's disease patients

AUTHOR CONTACT: Marios Politis
Imperial College London, London, , GBR
Phone: +4402083833754; E-mail:

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TITLE: Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

AUTHOR CONTACT: Philippe Lefebvre
Phone: +33.3209774220; E-mail:

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TITLE: Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance

Yale University School of Medicine, New Haven, CT, USA
Phone: 203-737-4170; Fax: 203-785-4904; E-mail:

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TITLE: Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

AUTHOR CONTACT: Nicholas Leeper
Stanford University School of Medicine, Stanford, CA, USA
Phone: 415-794-7712; E-mail:

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TITLE: Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome

AUTHOR CONTACT: Francesco Ramirez
Mount Sinai School of Medicine, New York, NY, USA
Phone: 212-241-7237; Fax: 212-996-7214; E-mail:

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TITLE: Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

AUTHOR CONTACT: Jeffrey Schelling
Case Western Reserve University, Cleveland, OH, USA
Phone: (216)778-3079; Fax: (216)778-4321; E-mail:

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TITLE: Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Phone: 215-823-5800 ext 3892; Fax: 215-349-5977; E-mail:

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TITLE: Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

Duke University Medical Center, Durham, NC, USA
Phone: 919-684-9687; E-mail:

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