Cells usually self-destruct when irreparable glitches occur in their DNA. Programmed cell death, or apoptosis, helps insure that cells with damaged DNA do not grow and replicate to produce more mutated cells. Apoptosis thereby helps protect and insure the survival of the organism.
At the GSA Drosophila Research Conference, TinTin Su, Ph.D., will report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.
Dr. Su and her collaborators at University of Colorado, Boulder used ionizing radiation (IR) to induce DNA damage and apoptosis in cells of the wing imaginal disc, the immature form of the fly's wings. The neighboring cells responded by activating bantam, a microRNA. As a result, the neighboring cells became more difficult to kill by IR.
The scientists determined that the key to this process was the receptor tyrosine kinase Tie. The dying cell's signal turned on Tie, thereby activating the short microRNA molecule bantam.
Previously the only known role for Tie in fruit flies was in long-range signaling in border cell migration. Although Tie is not required for normal larval development, it becomes necessary for survival after radiation exposure, Dr. Su noted.
The dying cell's signaling its neighbors to protect themselves from apoptosis challenges the long held view that cells in the vicinity of dying, irradiated cells become more prone to death. The results of the experiments conducted by Dr. Su and her collaborators also complement previous studies that showed that a larval disc cell's death leads to proliferation of cells in the disc.
If this protective mechanism also operates in mammals, it may affect the results of the sequential use of cytotoxic agents and radiation in cancer therapy, she pointed out.
Abstract: "Dying cells protect survivors from radiation-induced cell death." TinTin Su, Amber Bilak, Lyle Uyetake. MCD Biology, University of Colorado, Boulder, CO.
Founded in 1931, the Genetics Society of America (GSA) is the professional scientific society for genetics researchers and educators. The Society's more than 5,000 members worldwide work to deepen our understanding of the living world by advancing the field of genetics, from the molecular to the population level. GSA promotes research and fosters communication through a number of GSA-sponsored conferences including regular meetings that focus on particular model organisms. GSA publishes two peer-reviewed, peeredited scholarly journals: GENETICS, which has published high quality original research across the breadth of the field since 1916, and G3: Genes|Genomes|Genetics, an open-access journal launched in 2011 to disseminate high quality foundational research in genetics and genomics. The society also has a deep commitment to education and fostering the next generation of scholars in the field. For more information, please visit http://www.genetics-gsa.org/. Also follow GSA on Facebook at facebook.com/GeneticsGSA and on Twitter@GeneticsGSA.
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