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PUBLIC RELEASE DATE:
21-Mar-2014

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Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

A study using Drosophila flies reveals new regulatory mechanisms of cell migration

The study by Sofia J. Ara˙jo sheds light on the fields of development, wound healing, angiogenesis, and tumour invasion, processes in which cell migration is crucial

IMAGE: Scientists Sofia Araújo (left) and Elisenda Butí presented the results in PLoS One.

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Cell migration is highly coordinated and occurs in processes such as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invasion. For the successful control of cell movement, this process has to be determined and maintained with great precision. In this study, the scientists used tracheal cells of the fruit fly Drosophila melanogaster to unravel the signalling mechanism involved in the regulation of cell movements.

The research describes a new molecular component that controls the expression of a molecule named Fibroblast Growth Factor (FGF) in Drosophila embryos. The importance of FGF in cell migration was already known but little information was available on its genetic regulation. In the study, Ara˙jo and her team have discovered that a protein called Hedgehog, known to be involved in morphogenesis, regulates FGF expression.

IMAGE: Tracheas of the fruit fly Drosophila melanogaster (in blue and red) are a good model to study cell migration.

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"This is the first time that a direct connection has been demonstrated between the Hedgehog pathway and an increase in FGF during cell migration," says Ara˙jo.

"The results are really interesting for biomedicine," explains the researcher, "as the Hedgehog pathway is overexpressed in some of the most invasive tumours, such as the most common kind of skin cancer."

The team explains that this is a step forward for research into cell migration mechanisms and that future applications will emerge as further investigation and studies are conducted.

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Reference article:

Hedgehog is a positive regulator of FGF signalling during embryonic cell migration
Elisenda ButÝ, Duarte Mesquita and Sofia J. Ara˙jo
Plos One (2014) 10.1371/journal.pone.0092682



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